How reliably can algorithms identify eosinophilic asthma phenotypes using non-invasive biomarkers?

Diana Betancor*, José María Olaguibel, José Manuel Rodrigo-Muñoz, Ebymar Arismendi, Pilar Barranco, Blanca Barroso, Irina Bobolea, Blanca Cárdaba, María Jesús Cruz, Elena Curto, Victoria Del Pozo, Francisco Javier González-Barcala, Carlos Martínez-Rivera, Joaquim Mullol, Xavier Muñoz, Cesar Picado, Vicente Plaza, Santiago Quirce, Manuel Jorge Rial, Lorena SotoAntonio Valero, Marcela Valverde-Monge, Joaquin Sastre

*Autor corresponent d’aquest treball

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Resum

Background and Aims: Asthma is a heterogeneous respiratory disease that encompasses different inflammatory and functional endophenotypes. Many non-invasive biomarkers has been investigated to its pathobiology. Heany et al proposed a clinical algorithm that classifies severe asthmatic patients into likely-eosinophilic phenotypes, based on accessible biomarkers: PBE, current treatment, FeNO, presence of nasal polyps (NP) and age of onset. Materials and Methods: We assessed the concordance between the algorithm proposed by Heany et al. with sputum examination, the gold standard, in 145 asthmatic patients of the MEGA cohort with varying grades of severity. Results: No correlation was found between both classifications 0.025 (CI = 0.013–0.037). Moreover, no relationship was found between sputum eosinophilia and peripheral blood eosinophilia count in the total studied population. Discussion and Conclusion: In conclusion, our results suggest that grouping the biomarkers proposed by Heany et al. are insufficient to diagnose eosinophilic phenotypes in asthmatic patients. Sputum analysis remains the gold standard to assess airway inflammation.

Idioma originalAnglès
Número d’articlee12182
RevistaClinical and Translational Allergy
Volum12
Número8
DOIs
Estat de la publicacióPublicada - 20 d’ag. 2022

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