HLA class I and II alleles and response to treatment with interferon-beta in relapsing-remitting multiple sclerosis

M. Comabella; M. Fernandez-Arquero; J. Rio; A. Guinea; M. C. Cenit; E. G. de la Concha; X. Montalban

doi:10.1016/j.jneuroim.2009.01.012

HLA class I and II alleles and response to treatment with interferon-beta in relapsing-remitting multiple sclerosis

M. Comabella, M. Fernandez-Arquero, J. Rio, A. Guinea, M. C. Cenit, E. G. de la Concha, X. Montalban

Departament de Medicina

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31 Cites (Scopus)

Resum

In the present study, we investigated the influence of HLA class I and class 11 genes in the response to interferon-beta (IFN beta) in multiple sclerosis (MS) patients. HLA-A, -B, -C, -DRB1, -DQA1, and -DQB1 DNA typing was performed by polymerase chain reaction-sequence-specific oligonucleotide (PCR-SSO) in a cohort of 149 relapsing-remitting MS patients classified into IFN beta responders (n = 74) and non-responders (n = 75) based on stringent clinical criteria. Distribution of HLA class I and class II alleles individually and the HLA-DR2 haplotype was similar between responders and non-responders to treatment. These findings do not support a role of the HLA class I and class II genes as modifiers of the response to IFN beta. (C) 2009 Elsevier B.V. All rights reserved.

Idioma original	Anglès
Pàgines (de-a)	116-119
Nombre de pàgines	4
Revista	Journal of Neuroimmunology
Volum	210
Número	1-2
DOIs	https://doi.org/10.1016/j.jneuroim.2009.01.012
Estat de la publicació	Publicada - 29 de maig 2009

Paraules clau

HLA class I
HLA class II
Interferon-beta
Multiple sclerosis

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10.1016/j.jneuroim.2009.01.012

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title = "HLA class I and II alleles and response to treatment with interferon-beta in relapsing-remitting multiple sclerosis",

abstract = "In the present study, we investigated the influence of HLA class I and class 11 genes in the response to interferon-beta (IFN beta) in multiple sclerosis (MS) patients. HLA-A, -B, -C, -DRB1, -DQA1, and -DQB1 DNA typing was performed by polymerase chain reaction-sequence-specific oligonucleotide (PCR-SSO) in a cohort of 149 relapsing-remitting MS patients classified into IFN beta responders (n = 74) and non-responders (n = 75) based on stringent clinical criteria. Distribution of HLA class I and class II alleles individually and the HLA-DR2 haplotype was similar between responders and non-responders to treatment. These findings do not support a role of the HLA class I and class II genes as modifiers of the response to IFN beta. (C) 2009 Elsevier B.V. All rights reserved.",

keywords = "HLA class I, HLA class II, Interferon-beta, Multiple sclerosis, HLA class I, HLA class II, Interferon-beta, Multiple sclerosis, HLA class I, HLA class II, Interferon-beta, Multiple sclerosis",

author = "M. Comabella and M. Fernandez-Arquero and J. Rio and A. Guinea and Cenit, \{M. C.\} and \{de la Concha\}, \{E. G.\} and X. Montalban",

year = "2009",

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doi = "10.1016/j.jneuroim.2009.01.012",

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AU - Comabella, M.

AU - Fernandez-Arquero, M.

AU - Rio, J.

AU - Guinea, A.

AU - Cenit, M. C.

AU - de la Concha, E. G.

AU - Montalban, X.

PY - 2009/5/29

Y1 - 2009/5/29

N2 - In the present study, we investigated the influence of HLA class I and class 11 genes in the response to interferon-beta (IFN beta) in multiple sclerosis (MS) patients. HLA-A, -B, -C, -DRB1, -DQA1, and -DQB1 DNA typing was performed by polymerase chain reaction-sequence-specific oligonucleotide (PCR-SSO) in a cohort of 149 relapsing-remitting MS patients classified into IFN beta responders (n = 74) and non-responders (n = 75) based on stringent clinical criteria. Distribution of HLA class I and class II alleles individually and the HLA-DR2 haplotype was similar between responders and non-responders to treatment. These findings do not support a role of the HLA class I and class II genes as modifiers of the response to IFN beta. (C) 2009 Elsevier B.V. All rights reserved.

AB - In the present study, we investigated the influence of HLA class I and class 11 genes in the response to interferon-beta (IFN beta) in multiple sclerosis (MS) patients. HLA-A, -B, -C, -DRB1, -DQA1, and -DQB1 DNA typing was performed by polymerase chain reaction-sequence-specific oligonucleotide (PCR-SSO) in a cohort of 149 relapsing-remitting MS patients classified into IFN beta responders (n = 74) and non-responders (n = 75) based on stringent clinical criteria. Distribution of HLA class I and class II alleles individually and the HLA-DR2 haplotype was similar between responders and non-responders to treatment. These findings do not support a role of the HLA class I and class II genes as modifiers of the response to IFN beta. (C) 2009 Elsevier B.V. All rights reserved.

KW - HLA class I

KW - HLA class II

KW - Interferon-beta

KW - Multiple sclerosis

KW - HLA class I

KW - HLA class II

KW - Interferon-beta

KW - Multiple sclerosis

KW - HLA class I

KW - HLA class II

KW - Interferon-beta

KW - Multiple sclerosis

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JF - Journal of Neuroimmunology

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ER -

HLA class I and II alleles and response to treatment with interferon-beta in relapsing-remitting multiple sclerosis

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