H. pylori eradication does not reduce paraprotein levels in monoclonal gammopathy of unknown significance (MGUS): A prospective cohort study

Juan Alfonso Soler; Mercé Güell; Meritxell Bricullé; Antoni Gavarró; Imma Roig; Jordi Sanchez; Javier P. Gisbert; Pilar García; Albert Villoria; Xavier Calvet

doi:10.1007/s00277-008-0684-4

H. pylori eradication does not reduce paraprotein levels in monoclonal gammopathy of unknown significance (MGUS): A prospective cohort study

Juan Alfonso Soler, Mercé Güell, Meritxell Bricullé, Antoni Gavarró, Imma Roig, Jordi Sanchez, Javier P. Gisbert, Pilar García, Albert Villoria, Xavier Calvet

Departament de Medicina

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Monoclonal gammopathy of unknown significance (MGUS) is a chronic haematological alteration that carries a 1% risk per year of malignant evolution. The origin of this disturbance remains unknown. Previous reports have suggested that a subgroup of patients presenting MGUS might cure after Helicobacter pylori eradication. This study evaluates the effect of H. pylori eradication in a cohort of 30 patients with MGUS. A 7-day clarithromycin-based triple treatment was prescribed to patients with MGUS infected with H. pylori. Quantification of the monoclonal component was performed at inclusion and at least 12 months after treatment. The monoclonal component persisted unchanged in all patients who cured the H. pylori infection. © Springer-Verlag 2009.

Idioma original	Anglès
Pàgines (de-a)	769-773
Revista	Annals of Hematology
Volum	88
DOIs	https://doi.org/10.1007/s00277-008-0684-4
Estat de la publicació	Publicada - 23 de gen. 2009

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10.1007/s00277-008-0684-4

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title = "H. pylori eradication does not reduce paraprotein levels in monoclonal gammopathy of unknown significance (MGUS): A prospective cohort study",

abstract = "Monoclonal gammopathy of unknown significance (MGUS) is a chronic haematological alteration that carries a 1% risk per year of malignant evolution. The origin of this disturbance remains unknown. Previous reports have suggested that a subgroup of patients presenting MGUS might cure after Helicobacter pylori eradication. This study evaluates the effect of H. pylori eradication in a cohort of 30 patients with MGUS. A 7-day clarithromycin-based triple treatment was prescribed to patients with MGUS infected with H. pylori. Quantification of the monoclonal component was performed at inclusion and at least 12 months after treatment. The monoclonal component persisted unchanged in all patients who cured the H. pylori infection. {\textcopyright} Springer-Verlag 2009.",

keywords = "Eradication therapy, Helicobacter pylori, Monoclonal gammopathy of unknown significance",

author = "Soler, {Juan Alfonso} and Merc{\'e} G{\"u}ell and Meritxell Bricull{\'e} and Antoni Gavarr{\'o} and Imma Roig and Jordi Sanchez and Gisbert, {Javier P.} and Pilar Garc{\'i}a and Albert Villoria and Xavier Calvet",

year = "2009",

month = jan,

day = "23",

doi = "10.1007/s00277-008-0684-4",

language = "English",

volume = "88",

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TY - JOUR

T1 - H. pylori eradication does not reduce paraprotein levels in monoclonal gammopathy of unknown significance (MGUS): A prospective cohort study

AU - Soler, Juan Alfonso

AU - Güell, Mercé

AU - Bricullé, Meritxell

AU - Gavarró, Antoni

AU - Roig, Imma

AU - Sanchez, Jordi

AU - Gisbert, Javier P.

AU - García, Pilar

AU - Villoria, Albert

AU - Calvet, Xavier

PY - 2009/1/23

Y1 - 2009/1/23

N2 - Monoclonal gammopathy of unknown significance (MGUS) is a chronic haematological alteration that carries a 1% risk per year of malignant evolution. The origin of this disturbance remains unknown. Previous reports have suggested that a subgroup of patients presenting MGUS might cure after Helicobacter pylori eradication. This study evaluates the effect of H. pylori eradication in a cohort of 30 patients with MGUS. A 7-day clarithromycin-based triple treatment was prescribed to patients with MGUS infected with H. pylori. Quantification of the monoclonal component was performed at inclusion and at least 12 months after treatment. The monoclonal component persisted unchanged in all patients who cured the H. pylori infection. © Springer-Verlag 2009.

AB - Monoclonal gammopathy of unknown significance (MGUS) is a chronic haematological alteration that carries a 1% risk per year of malignant evolution. The origin of this disturbance remains unknown. Previous reports have suggested that a subgroup of patients presenting MGUS might cure after Helicobacter pylori eradication. This study evaluates the effect of H. pylori eradication in a cohort of 30 patients with MGUS. A 7-day clarithromycin-based triple treatment was prescribed to patients with MGUS infected with H. pylori. Quantification of the monoclonal component was performed at inclusion and at least 12 months after treatment. The monoclonal component persisted unchanged in all patients who cured the H. pylori infection. © Springer-Verlag 2009.

KW - Eradication therapy

KW - Helicobacter pylori

KW - Monoclonal gammopathy of unknown significance

U2 - 10.1007/s00277-008-0684-4

DO - 10.1007/s00277-008-0684-4

M3 - Article

SN - 0939-5555

VL - 88

SP - 769

EP - 773

JO - Annals of Hematology

JF - Annals of Hematology

ER -

H. pylori eradication does not reduce paraprotein levels in monoclonal gammopathy of unknown significance (MGUS): A prospective cohort study

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