Gold nanoparticles exposure modulates antioxidant and innate immune gene expression in the gills of Sparus aurata

Pinanong Na-Phatthalung, Mariana Teles, Lluís Tort, Miguel Oliveira

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Resum

© 2018 Elsevier Inc. This study aimed to assess antioxidant and immune gene transcription alterations in the gills of Sparus aurata exposed during 96 h to 4, 80, and 1600 μg/L of gold nanoparticles (AuNPs) coated with citrate or polyvinyl pyrrolidone (PVP). After 96 h of exposure, gr and cat mRNA levels decreased for all tested concentrations of AuNPs, for both coatings. Instead, gst3 mRNA increased after exposure to 1600 μg/L AuNPs (both coatings) and prdx6 increased after exposure to 1600 μg/L AuNPs-citrate. Concerning immune genes, il1β mRNA levels increased after exposure to 80 μg/L AuNPs-citrate and 1600 μg/L AuNPs-PVP and cox2 mRNA showed increased levels in fish exposed to 1600 μg/L AuNPs-citrate. Results indicate that AuNPs with distinct coatings induced different gene expression profiles in gills, though most of the studied genes remained unaltered for the tested conditions.
Idioma originalEnglish
Pàgines (de-a)430-434
RevistaGenomics
Volum110
DOIs
Estat de la publicacióPublicada - 1 de nov. 2018

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