Genotoxicity of tritiated water in human lymphocytes

G. Ribas; E. Carbonell; N. Xamena; A. Creus; R. Marcos

doi:10.1016/0378-4274(94)90145-7

Genotoxicity of tritiated water in human lymphocytes

G. Ribas, E. Carbonell, N. Xamena, A. Creus, R. Marcos

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The present study was carried out to evaluate the genotoxicity of tritium, administered as tritiated water, in peripheral blood human lymphocyte cultures. Sister-chromatid exchanges (SCE) and chromosome aberrations (CA) were scored as genetic endpoints. From our results we can conclude that β-radiation from low concentrations of tritium was able to induce a significant increase in the frequency of CA, although it was ineffective in increasing the frequency of SCE. © 1994.

Idioma original	English
Pàgines (de-a)	63-69
Revista	Toxicology Letters
Volum	70
Número	1
DOIs	https://doi.org/10.1016/0378-4274(94)90145-7
Estat de la publicació	Publicada - 1 de gen. 1994

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10.1016/0378-4274(94)90145-7

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title = "Genotoxicity of tritiated water in human lymphocytes",

abstract = "The present study was carried out to evaluate the genotoxicity of tritium, administered as tritiated water, in peripheral blood human lymphocyte cultures. Sister-chromatid exchanges (SCE) and chromosome aberrations (CA) were scored as genetic endpoints. From our results we can conclude that β-radiation from low concentrations of tritium was able to induce a significant increase in the frequency of CA, although it was ineffective in increasing the frequency of SCE. {\textcopyright} 1994.",

keywords = "Chromosome aberrations, Genotoxicity, Human lymphocyte, Sister-chromatid exchange, Tritiated water",

author = "G. Ribas and E. Carbonell and N. Xamena and A. Creus and R. Marcos",

year = "1994",

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doi = "10.1016/0378-4274(94)90145-7",

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T1 - Genotoxicity of tritiated water in human lymphocytes

AU - Ribas, G.

AU - Carbonell, E.

AU - Xamena, N.

AU - Creus, A.

AU - Marcos, R.

PY - 1994/1/1

Y1 - 1994/1/1

N2 - The present study was carried out to evaluate the genotoxicity of tritium, administered as tritiated water, in peripheral blood human lymphocyte cultures. Sister-chromatid exchanges (SCE) and chromosome aberrations (CA) were scored as genetic endpoints. From our results we can conclude that β-radiation from low concentrations of tritium was able to induce a significant increase in the frequency of CA, although it was ineffective in increasing the frequency of SCE. © 1994.

AB - The present study was carried out to evaluate the genotoxicity of tritium, administered as tritiated water, in peripheral blood human lymphocyte cultures. Sister-chromatid exchanges (SCE) and chromosome aberrations (CA) were scored as genetic endpoints. From our results we can conclude that β-radiation from low concentrations of tritium was able to induce a significant increase in the frequency of CA, although it was ineffective in increasing the frequency of SCE. © 1994.

KW - Chromosome aberrations

KW - Genotoxicity

KW - Human lymphocyte

KW - Sister-chromatid exchange

KW - Tritiated water

U2 - 10.1016/0378-4274(94)90145-7

DO - 10.1016/0378-4274(94)90145-7

M3 - Article

SN - 0378-4274

VL - 70

SP - 63

EP - 69

JO - Toxicology Letters

JF - Toxicology Letters

IS - 1

ER -

Genotoxicity of tritiated water in human lymphocytes

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