Genome-wide Association Study of Asthma Exacerbations in the Spanish Population

Elena Martín González; Javier Pérez García; Mario Martín Almeida; José María Hernández Pérez; Ruperto González Pérez; Olaia Sardón Prado; Jose Antonio Pérez Pérez; Mario A. González Carracedo; Paloma Poza Guedes; María Inmaculada Sánchez Machín; Elena Mederos Luis; Paula Corcuera; Leyre López Fernández; Berta Román Bernal; Luis Manuel González García; María Jesús Cruz; Francisco Javier González Barcala; Carlos Martínez Rivera; Joaquim Mullol Miret; Xavier Muñoz; José María Olaguíbel Rivera; Vicente Plaza Moral; Santiago Quirce Gancedo; Antonio Luis Valero Santiago; Joaquín Sastre Merlín; Victoria del Pozo Abejón; Jesús Manuel Fernández Villar; Luis Fabián Lorenzo Díaz; María del Mar del Pino Yanes

doi:10.1016/j.arbres.2025.03.012

Genome-wide Association Study of Asthma Exacerbations in the Spanish Population

Elena Martín González, Javier Pérez García, Mario Martín Almeida, José María Hernández Pérez, Ruperto González Pérez, Olaia Sardón Prado, Jose Antonio Pérez Pérez, Mario A. González Carracedo, Paloma Poza Guedes, María Inmaculada Sánchez Machín, Elena Mederos Luis, Paula Corcuera, Leyre López Fernández, Berta Román Bernal, Luis Manuel González García, María Jesús Cruz, Francisco Javier González Barcala, Carlos Martínez Rivera, Joaquim Mullol Miret, Xavier MuñozJosé María Olaguíbel Rivera, Vicente Plaza Moral, Santiago Quirce Gancedo, Antonio Luis Valero Santiago, Joaquín Sastre Merlín, Victoria del Pozo Abejón, Jesús Manuel Fernández Villar, Luis Fabián Lorenzo Díaz, María del Mar del Pino Yanes

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This work was funded by grant PID2020-116274RB-I00 funded by MICIU/AEI/10.13039/501100011033 (Spanish Ministry of Science, Innovation, and Universities) and grant PIFIISC22/24 by Fundación Canaria Instituto de Investigación Sanitaria de Canarias (FIISC). This work was alsopartially fundedby a grantfromSociedad Espanola ˜ de Alergología e Inmunología Clínica (SEAIC) to RGP, grant SAF2017-83417R by MICIU/AEI/10.13039/501100011033 and by “ERDF A way of making Europe” and grant A23100219 from the CSL Behring. EM-G was funded by a fellowship (TESIS2022010045) co-financed by the Canarian Agency for Research, Innovation and the Information Society ofthe Counseling of Universities, Science and Innovation and Culture and by the European Social Fund Plus (ESF+) Integrated Operational Program of the Canary Islands 2021–2027, Axis 3 Priority Theme 74 (85%). JP-G was funded by fellowship FPU19/02175 (Formación de Profesorado Universitario Program) from the MICIU. MM-A was funded by fellowships FPI2024010123 co-financed by the Canarian Agency for Research, Innovation and the Information Society of the Counseling of Universities, Science and Innovation and Culture and by the European Social Fund Plus (ESF+) Integrated Operational Program ofthe Canary Islands 2021-2027,Axis 3 Priority Theme 74 (85%) and FPU23/02667 (Formación de Profesorado Universitario Program) from the Spanish Ministry of Science, Innovation and Universities. JV was funded by Instituto de Salud Carlos III, Madrid, Spain (PI19/00141, AC21 2/00039), ERAPerMed (JTC 2021),the European Regional Development Funds, FundaciónCanaria Institutode Investigación Sanitaria de Canarias, Spain (PIFIISC21-36), and Asociación Científica Pulmón y Ventilación Mecánica, Spain. JV and MP-Y also received funding from CIBER – Consorcio Centro de Investigación Biomédica en Red (CIBERES), Instituto de Salud Carlos III (ISCIII), and European Regional Development Fund (CB06/06/1088).

Idioma original	Anglès
Pàgines (de-a)	490-494
Nombre de pàgines	5
Revista	Archivos de Bronconeumologia
Volum	61
Número	8
DOIs	https://doi.org/10.1016/j.arbres.2025.03.012
Estat de la publicació	Publicada - d’ag. 2025

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Martín González, E., Pérez García, J., Martín Almeida, M., Hernández Pérez, J. M., González Pérez, R., Sardón Prado, O., Pérez Pérez, J. A., González Carracedo, M. A., Poza Guedes, P., Sánchez Machín, M. I., Mederos Luis, E., Corcuera, P., López Fernández, L., Román Bernal, B., González García, L. M., Cruz, M. J., González Barcala, F. J., Martínez Rivera, C., Mullol Miret, J., ... Pino Yanes, M. D. M. D. (2025). Genome-wide Association Study of Asthma Exacerbations in the Spanish Population. Archivos de Bronconeumologia, 61(8), 490-494. https://doi.org/10.1016/j.arbres.2025.03.012

@article{0edb9288f25f4c05b7000e872da4cb98,

title = "Genome-wide Association Study of Asthma Exacerbations in the Spanish Population",

abstract = "This work was funded by grant PID2020-116274RB-I00 funded by MICIU/AEI/10.13039/501100011033 (Spanish Ministry of Science, Innovation, and Universities) and grant PIFIISC22/24 by Fundaci{\'o}n Canaria Instituto de Investigaci{\'o}n Sanitaria de Canarias (FIISC). This work was alsopartially fundedby a grantfromSociedad Espanola ˜ de Alergolog{\'i}a e Inmunolog{\'i}a Cl{\'i}nica (SEAIC) to RGP, grant SAF2017-83417R by MICIU/AEI/10.13039/501100011033 and by “ERDF A way of making Europe” and grant A23100219 from the CSL Behring. EM-G was funded by a fellowship (TESIS2022010045) co-financed by the Canarian Agency for Research, Innovation and the Information Society ofthe Counseling of Universities, Science and Innovation and Culture and by the European Social Fund Plus (ESF+) Integrated Operational Program of the Canary Islands 2021–2027, Axis 3 Priority Theme 74 (85\%). JP-G was funded by fellowship FPU19/02175 (Formaci{\'o}n de Profesorado Universitario Program) from the MICIU. MM-A was funded by fellowships FPI2024010123 co-financed by the Canarian Agency for Research, Innovation and the Information Society of the Counseling of Universities, Science and Innovation and Culture and by the European Social Fund Plus (ESF+) Integrated Operational Program ofthe Canary Islands 2021-2027,Axis 3 Priority Theme 74 (85\%) and FPU23/02667 (Formaci{\'o}n de Profesorado Universitario Program) from the Spanish Ministry of Science, Innovation and Universities. JV was funded by Instituto de Salud Carlos III, Madrid, Spain (PI19/00141, AC21 2/00039), ERAPerMed (JTC 2021),the European Regional Development Funds, Fundaci{\'o}nCanaria Institutode Investigaci{\'o}n Sanitaria de Canarias, Spain (PIFIISC21-36), and Asociaci{\'o}n Cient{\'i}fica Pulm{\'o}n y Ventilaci{\'o}n Mec{\'a}nica, Spain. JV and MP-Y also received funding from CIBER – Consorcio Centro de Investigaci{\'o}n Biom{\'e}dica en Red (CIBERES), Instituto de Salud Carlos III (ISCIII), and European Regional Development Fund (CB06/06/1088).",

author = "\{Mart{\'i}n Gonz{\'a}lez\}, Elena and \{P{\'e}rez Garc{\'i}a\}, Javier and \{Mart{\'i}n Almeida\}, Mario and \{Hern{\'a}ndez P{\'e}rez\}, \{Jos{\'e} Mar{\'i}a\} and \{Gonz{\'a}lez P{\'e}rez\}, Ruperto and \{Sard{\'o}n Prado\}, Olaia and \{P{\'e}rez P{\'e}rez\}, \{Jose Antonio\} and \{Gonz{\'a}lez Carracedo\}, \{Mario A.\} and \{Poza Guedes\}, Paloma and \{S{\'a}nchez Mach{\'i}n\}, \{Mar{\'i}a Inmaculada\} and \{Mederos Luis\}, Elena and Paula Corcuera and \{L{\'o}pez Fern{\'a}ndez\}, Leyre and \{Rom{\'a}n Bernal\}, Berta and \{Gonz{\'a}lez Garc{\'i}a\}, \{Luis Manuel\} and Cruz, \{Mar{\'i}a Jes{\'u}s\} and \{Gonz{\'a}lez Barcala\}, \{Francisco Javier\} and \{Mart{\'i}nez Rivera\}, Carlos and \{Mullol Miret\}, Joaquim and Xavier Mu{\~n}oz and \{Olagu{\'i}bel Rivera\}, \{Jos{\'e} Mar{\'i}a\} and \{Plaza Moral\}, Vicente and \{Quirce Gancedo\}, Santiago and \{Valero Santiago\}, \{Antonio Luis\} and \{Sastre Merl{\'i}n\}, Joaqu{\'i}n and \{Pozo Abej{\'o}n\}, \{Victoria del\} and \{Fern{\'a}ndez Villar\}, \{Jes{\'u}s Manuel\} and \{Lorenzo D{\'i}az\}, \{Luis Fabi{\'a}n\} and \{Pino Yanes\}, \{Mar{\'i}a del Mar del\}",

year = "2025",

month = aug,

doi = "10.1016/j.arbres.2025.03.012",

language = "English",

volume = "61",

pages = "490--494",

number = "8",

}

Martín González, E, Pérez García, J, Martín Almeida, M, Hernández Pérez, JM, González Pérez, R, Sardón Prado, O, Pérez Pérez, JA, González Carracedo, MA, Poza Guedes, P, Sánchez Machín, MI, Mederos Luis, E, Corcuera, P, López Fernández, L, Román Bernal, B, González García, LM, Cruz, MJ, González Barcala, FJ, Martínez Rivera, C, Mullol Miret, J, Muñoz, X, Olaguíbel Rivera, JM, Plaza Moral, V, Quirce Gancedo, S, Valero Santiago, AL, Sastre Merlín, J, Pozo Abejón, VD, Fernández Villar, JM, Lorenzo Díaz, LF & Pino Yanes, MDMD 2025, 'Genome-wide Association Study of Asthma Exacerbations in the Spanish Population', Archivos de Bronconeumologia, vol. 61, núm. 8, pàg. 490-494. https://doi.org/10.1016/j.arbres.2025.03.012

TY - JOUR

T1 - Genome-wide Association Study of Asthma Exacerbations in the Spanish Population

AU - Martín González, Elena

AU - Pérez García, Javier

AU - Martín Almeida, Mario

AU - Hernández Pérez, José María

AU - González Pérez, Ruperto

AU - Sardón Prado, Olaia

AU - Pérez Pérez, Jose Antonio

AU - González Carracedo, Mario A.

AU - Poza Guedes, Paloma

AU - Sánchez Machín, María Inmaculada

AU - Mederos Luis, Elena

AU - Corcuera, Paula

AU - López Fernández, Leyre

AU - Román Bernal, Berta

AU - González García, Luis Manuel

AU - Cruz, María Jesús

AU - González Barcala, Francisco Javier

AU - Martínez Rivera, Carlos

AU - Mullol Miret, Joaquim

AU - Muñoz, Xavier

AU - Olaguíbel Rivera, José María

AU - Plaza Moral, Vicente

AU - Quirce Gancedo, Santiago

AU - Valero Santiago, Antonio Luis

AU - Sastre Merlín, Joaquín

AU - Pozo Abejón, Victoria del

AU - Fernández Villar, Jesús Manuel

AU - Lorenzo Díaz, Luis Fabián

AU - Pino Yanes, María del Mar del

PY - 2025/8

Y1 - 2025/8

N2 - This work was funded by grant PID2020-116274RB-I00 funded by MICIU/AEI/10.13039/501100011033 (Spanish Ministry of Science, Innovation, and Universities) and grant PIFIISC22/24 by Fundación Canaria Instituto de Investigación Sanitaria de Canarias (FIISC). This work was alsopartially fundedby a grantfromSociedad Espanola ˜ de Alergología e Inmunología Clínica (SEAIC) to RGP, grant SAF2017-83417R by MICIU/AEI/10.13039/501100011033 and by “ERDF A way of making Europe” and grant A23100219 from the CSL Behring. EM-G was funded by a fellowship (TESIS2022010045) co-financed by the Canarian Agency for Research, Innovation and the Information Society ofthe Counseling of Universities, Science and Innovation and Culture and by the European Social Fund Plus (ESF+) Integrated Operational Program of the Canary Islands 2021–2027, Axis 3 Priority Theme 74 (85%). JP-G was funded by fellowship FPU19/02175 (Formación de Profesorado Universitario Program) from the MICIU. MM-A was funded by fellowships FPI2024010123 co-financed by the Canarian Agency for Research, Innovation and the Information Society of the Counseling of Universities, Science and Innovation and Culture and by the European Social Fund Plus (ESF+) Integrated Operational Program ofthe Canary Islands 2021-2027,Axis 3 Priority Theme 74 (85%) and FPU23/02667 (Formación de Profesorado Universitario Program) from the Spanish Ministry of Science, Innovation and Universities. JV was funded by Instituto de Salud Carlos III, Madrid, Spain (PI19/00141, AC21 2/00039), ERAPerMed (JTC 2021),the European Regional Development Funds, FundaciónCanaria Institutode Investigación Sanitaria de Canarias, Spain (PIFIISC21-36), and Asociación Científica Pulmón y Ventilación Mecánica, Spain. JV and MP-Y also received funding from CIBER – Consorcio Centro de Investigación Biomédica en Red (CIBERES), Instituto de Salud Carlos III (ISCIII), and European Regional Development Fund (CB06/06/1088).

AB - This work was funded by grant PID2020-116274RB-I00 funded by MICIU/AEI/10.13039/501100011033 (Spanish Ministry of Science, Innovation, and Universities) and grant PIFIISC22/24 by Fundación Canaria Instituto de Investigación Sanitaria de Canarias (FIISC). This work was alsopartially fundedby a grantfromSociedad Espanola ˜ de Alergología e Inmunología Clínica (SEAIC) to RGP, grant SAF2017-83417R by MICIU/AEI/10.13039/501100011033 and by “ERDF A way of making Europe” and grant A23100219 from the CSL Behring. EM-G was funded by a fellowship (TESIS2022010045) co-financed by the Canarian Agency for Research, Innovation and the Information Society ofthe Counseling of Universities, Science and Innovation and Culture and by the European Social Fund Plus (ESF+) Integrated Operational Program of the Canary Islands 2021–2027, Axis 3 Priority Theme 74 (85%). JP-G was funded by fellowship FPU19/02175 (Formación de Profesorado Universitario Program) from the MICIU. MM-A was funded by fellowships FPI2024010123 co-financed by the Canarian Agency for Research, Innovation and the Information Society of the Counseling of Universities, Science and Innovation and Culture and by the European Social Fund Plus (ESF+) Integrated Operational Program ofthe Canary Islands 2021-2027,Axis 3 Priority Theme 74 (85%) and FPU23/02667 (Formación de Profesorado Universitario Program) from the Spanish Ministry of Science, Innovation and Universities. JV was funded by Instituto de Salud Carlos III, Madrid, Spain (PI19/00141, AC21 2/00039), ERAPerMed (JTC 2021),the European Regional Development Funds, FundaciónCanaria Institutode Investigación Sanitaria de Canarias, Spain (PIFIISC21-36), and Asociación Científica Pulmón y Ventilación Mecánica, Spain. JV and MP-Y also received funding from CIBER – Consorcio Centro de Investigación Biomédica en Red (CIBERES), Instituto de Salud Carlos III (ISCIII), and European Regional Development Fund (CB06/06/1088).

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SN - 0300-2896

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SP - 490

EP - 494

JO - Archivos de Bronconeumologia

JF - Archivos de Bronconeumologia

IS - 8

ER -

Genome-wide Association Study of Asthma Exacerbations in the Spanish Population

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