TY - JOUR
T1 - Genetic variation in IL28B and treatment-induced clearance of hepatitis C virus in HIV-positive patients with acute and chronic hepatitis C
AU - Nattermann, Jacob
AU - Vogel, Martin
AU - Nischalke, Hans Dieter
AU - Danta, Mark
AU - Mauss, Stefan
AU - Stellbrink, Hans Jörg
AU - Baumgarten, Axel
AU - Mayr, Christoph
AU - Bruno, Raffaele
AU - Tural, Cristina
AU - Klausen, Gerd
AU - Clotet, Bonaventura
AU - Naumann, Uwe
AU - Lutz, Thomas
AU - Rausch, Michael
AU - Schewe, Knud
AU - Bienek, Bernhard
AU - Haerter, Georg
AU - Sauerbruch, Tilman
AU - Rockstroh, Juergen K.
AU - Spengler, Ulrich
PY - 2011/3/1
Y1 - 2011/3/1
N2 - Recently, a IL28B (rs 12979860) gene polymorphism was identified as a predictor for response to hepatits C virus-specific treatment in human immunodeficiency virus (HIV)-uninfected and -infected patients with chronic hepatitis C. In an analysis of HIV-infected patients with acute hepatitis C, we found that the IL28B genotype was associated with serum levels of hepatitis C virus RNA, g-GT, and CD4 cell count. In contrast to HIV-infected patients with chronic hepatitis C, the IL28B genotype was not significantly associated with treatment response rates in patients with acute hepatitis C. Thus, effects of the IL28B single-nucleotide polymorphism may differ in HIV-infected patients with chronic and acute hepatitis C. © The Author 2011. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved.
AB - Recently, a IL28B (rs 12979860) gene polymorphism was identified as a predictor for response to hepatits C virus-specific treatment in human immunodeficiency virus (HIV)-uninfected and -infected patients with chronic hepatitis C. In an analysis of HIV-infected patients with acute hepatitis C, we found that the IL28B genotype was associated with serum levels of hepatitis C virus RNA, g-GT, and CD4 cell count. In contrast to HIV-infected patients with chronic hepatitis C, the IL28B genotype was not significantly associated with treatment response rates in patients with acute hepatitis C. Thus, effects of the IL28B single-nucleotide polymorphism may differ in HIV-infected patients with chronic and acute hepatitis C. © The Author 2011. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved.
U2 - 10.1093/infdis/jiq098
DO - 10.1093/infdis/jiq098
M3 - Article
SN - 0022-1899
VL - 203
SP - 595
EP - 601
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
IS - 5
ER -
