TY - JOUR
T1 - Gas phase reactivity of Cu+-aromatic amino acids. An experimental and theoretical study
AU - Rimola, A.
AU - Sodupe, M.
AU - Tortajada, J.
AU - Rodríguez-Santiago, L.
PY - 2006/11/1
Y1 - 2006/11/1
N2 - The reactions between Cu+ and the four natural aromatic amino acids (AAarom = Phe, Tyr, Trp and His) have been investigated by means of electrospray ionization mass spectrometry. Metal cation complexes ([Cu AAarom]+) were formed in the electrospray source and collision-induced fragmentations of the most abundant isotopic form, [63Cu AAarom]+, were studied for each amino acid. The same fragmentation pattern is observed for all the amino acids, the most important peak corresponding in all cases to the loss of CH2O2. Among the four aromatic amino acids, the [Cu Phe]+ complex was selected for a computational study of the potential energy surface. Several mechanisms were studied at the B3LYP level and most of the observed fragmentations start with the metal cation insertion into the C{single bond}C backbone bond or into the C{single bond}R bond of the amino acid. © 2006 Elsevier B.V. All rights reserved.
AB - The reactions between Cu+ and the four natural aromatic amino acids (AAarom = Phe, Tyr, Trp and His) have been investigated by means of electrospray ionization mass spectrometry. Metal cation complexes ([Cu AAarom]+) were formed in the electrospray source and collision-induced fragmentations of the most abundant isotopic form, [63Cu AAarom]+, were studied for each amino acid. The same fragmentation pattern is observed for all the amino acids, the most important peak corresponding in all cases to the loss of CH2O2. Among the four aromatic amino acids, the [Cu Phe]+ complex was selected for a computational study of the potential energy surface. Several mechanisms were studied at the B3LYP level and most of the observed fragmentations start with the metal cation insertion into the C{single bond}C backbone bond or into the C{single bond}R bond of the amino acid. © 2006 Elsevier B.V. All rights reserved.
KW - Aromatic amino acids
KW - B3lyp
KW - ESI-CID
KW - Metal cation
U2 - 10.1016/j.ijms.2006.06.017
DO - 10.1016/j.ijms.2006.06.017
M3 - Article
SN - 1387-3806
VL - 257
SP - 60
EP - 69
JO - International Journal of Mass Spectrometry
JF - International Journal of Mass Spectrometry
IS - 1-3
ER -