From Inhibition of GABA-A Receptor-Mediated Synaptic Transmission by Conventional Antidepressants to Negative Allosteric Modulators of Alpha5-GABA-A Receptors as Putative Fast-Acting Antidepressant Drugs :: Closing the Circle?

Alberto Fernández-Teruel

doi:10.2174/1570159X19666211104144650

From Inhibition of GABA-A Receptor-Mediated Synaptic Transmission by Conventional Antidepressants to Negative Allosteric Modulators of Alpha5-GABA-A Receptors as Putative Fast-Acting Antidepressant Drugs : Closing the Circle?

Alberto Fernández-Teruel

Producció científica: Contribució a una revista › Article › Recerca › Avaluat per experts

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The present perspective paper shortly and specifically addresses the issues of whether inhibition of GABA-A receptor-mediated synaptic transmission may be involved in antidepressant-like actions and the therapeutic effects of conventional antidepressant (AD) drugs, and whether the recent development of negative allosteric modulators (NAMs) of the alpha5-GABA-A receptor may constitute significant progress in our knowledge on the neurobiology and the treatment of depression.

Idioma original	English
Pàgines (de-a)	85-89
Nombre de pàgines	5
Revista	Current Neuropharmacology
Volum	20
DOIs	https://doi.org/10.2174/1570159X19666211104144650
Estat de la publicació	Publicada - 2022

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10.2174/1570159X19666211104144650

https://ddd.uab.cat/record/292948

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PATRONES MADURATIVOS FRONTOCORTICALES Y COGNITIVOS, E INFLUENCIA DE LA EXPERIENCIA TEMPRANA, EN UN MODELO GENETICO DE RASGOS ASOCIADOS A LA ESQUIZOFRENIA, LAS RATAS RHA VS RLA
Fernandez Teruel, A. (Investigador/a principal), Aznar Kleijn, S. (Col.laborador/a), Cañete Ramírez, A. (Col.laborador/a), Giorgi, O. (Col.laborador/a), GIUSEPPA CORDA, M. (Col.laborador/a), Gonzalez-Maeso, J. (Col.laborador/a), Oliveras Puigdellivol, I. (Col.laborador/a), Sampedro Viana, D. (Col.laborador/a), Tobeña Pallares, A. (Investigador/a), Peralta Vallejo, N. (Col.laborador/a) & Del Río Álamos, C. (Col.laborador/a)
1/01/21 → 31/08/24
Projecte: Projectes i Ajuts a la Recerca

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title = "From Inhibition of GABA-A Receptor-Mediated Synaptic Transmission by Conventional Antidepressants to Negative Allosteric Modulators of Alpha5-GABA-A Receptors as Putative Fast-Acting Antidepressant Drugs :: Closing the Circle?",

abstract = "The present perspective paper shortly and specifically addresses the issues of whether inhibition of GABA-A receptor-mediated synaptic transmission may be involved in antidepressant-like actions and the therapeutic effects of conventional antidepressant (AD) drugs, and whether the recent development of negative allosteric modulators (NAMs) of the alpha5-GABA-A receptor may constitute significant progress in our knowledge on the neurobiology and the treatment of depression.",

keywords = "Antidepressant drugs, Conventional antidepressants, GABA-A transmission, GABA-A receptors, Modulators of alpha5-GABA-A, Negative allosteric modulators",

author = "Alberto Fern{\'a}ndez-Teruel",

year = "2022",

doi = "10.2174/1570159X19666211104144650",

language = "English",

volume = "20",

pages = "85--89",

journal = "Current Neuropharmacology",

issn = "1570-159X",

publisher = "Bentham Science Publishers B.V.",

}

From Inhibition of GABA-A Receptor-Mediated Synaptic Transmission by Conventional Antidepressants to Negative Allosteric Modulators of Alpha5-GABA-A Receptors as Putative Fast-Acting Antidepressant Drugs : Closing the Circle? / Fernández-Teruel, Alberto.
In: Current Neuropharmacology, Vol. 20, 2022, pàg. 85-89.

Producció científica: Contribució a una revista › Article › Recerca › Avaluat per experts

TY - JOUR

T1 - From Inhibition of GABA-A Receptor-Mediated Synaptic Transmission by Conventional Antidepressants to Negative Allosteric Modulators of Alpha5-GABA-A Receptors as Putative Fast-Acting Antidepressant Drugs :

T2 - Closing the Circle?

AU - Fernández-Teruel, Alberto

PY - 2022

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N2 - The present perspective paper shortly and specifically addresses the issues of whether inhibition of GABA-A receptor-mediated synaptic transmission may be involved in antidepressant-like actions and the therapeutic effects of conventional antidepressant (AD) drugs, and whether the recent development of negative allosteric modulators (NAMs) of the alpha5-GABA-A receptor may constitute significant progress in our knowledge on the neurobiology and the treatment of depression.

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KW - Conventional antidepressants

KW - GABA-A transmission

KW - GABA-A receptors

KW - Modulators of alpha5-GABA-A

KW - Negative allosteric modulators

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DO - 10.2174/1570159X19666211104144650

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From Inhibition of GABA-A Receptor-Mediated Synaptic Transmission by Conventional Antidepressants to Negative Allosteric Modulators of Alpha5-GABA-A Receptors as Putative Fast-Acting Antidepressant Drugs : Closing the Circle?

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PATRONES MADURATIVOS FRONTOCORTICALES Y COGNITIVOS, E INFLUENCIA DE LA EXPERIENCIA TEMPRANA, EN UN MODELO GENETICO DE RASGOS ASOCIADOS A LA ESQUIZOFRENIA, LAS RATAS RHA VS RLA

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