TY - JOUR
T1 - Frequency and prognostic significance of additional cytogenetic abnormalities to the Philadelphia chromosome in young and older adults with acute lymphoblastic leukemia
AU - Motlló, Cristina
AU - Ribera, Josep Maria
AU - Morgades, Mireia
AU - Granada, Isabel
AU - Montesinos, Pau
AU - Mercadal, Santiago
AU - González-Campos, José
AU - Moreno, María José
AU - Barba, Pere
AU - Cervera, Marta
AU - Barrios, Manuel
AU - Novo, Andrés
AU - Bernal, Teresa
AU - Hernández-Rivas, Jesús María
AU - Abella, Eugenia
AU - Amigo, María Luz
AU - Tormo, Mar
AU - Martino, Rodrigo
AU - Lavilla, Esperanza
AU - Bergua, Juan
AU - Serrano, Alfons
AU - García-Belmonte, Daniel
AU - Guàrdia, Ramon
AU - Grau, Javier
AU - Feliu, Evarist
PY - 2018/1/2
Y1 - 2018/1/2
N2 - © 2017 Informa UK Limited, trading as Taylor & Francis Group. About 25–35% of adult patients with acute lymphoblastic leukemia show the Philadelphia (Ph) chromosome. Few series have evaluated the prognosis of additional cytogenetic alterations (ACA) to the Ph chromosome. We analyzed the frequency, type and prognostic significance ofACA in adults (18–60 years) treated in the ALL-Ph-08 trial. Fifty-two out of 74 patients (70%) showed ACA and 19 (26%) presented monosomies associated with t(9;22) (monosomal karyotype, MK). Similar complete response (CR) rate, CR duration, overall survival and event-free survival (EFS) were observed in patients with or without ACA, but patients with MK showed shorter CR duration and EFS than the remaining. On multivariate analysis, the only variable with prognostic impact for CR duration and EFS was the presence of MK (p =.003 and p =.036, respectively). Although ACA associated with the Ph chromosome are frequent, only monosomies were associated with poor prognosis in this group of patients.
AB - © 2017 Informa UK Limited, trading as Taylor & Francis Group. About 25–35% of adult patients with acute lymphoblastic leukemia show the Philadelphia (Ph) chromosome. Few series have evaluated the prognosis of additional cytogenetic alterations (ACA) to the Ph chromosome. We analyzed the frequency, type and prognostic significance ofACA in adults (18–60 years) treated in the ALL-Ph-08 trial. Fifty-two out of 74 patients (70%) showed ACA and 19 (26%) presented monosomies associated with t(9;22) (monosomal karyotype, MK). Similar complete response (CR) rate, CR duration, overall survival and event-free survival (EFS) were observed in patients with or without ACA, but patients with MK showed shorter CR duration and EFS than the remaining. On multivariate analysis, the only variable with prognostic impact for CR duration and EFS was the presence of MK (p =.003 and p =.036, respectively). Although ACA associated with the Ph chromosome are frequent, only monosomies were associated with poor prognosis in this group of patients.
KW - Acute lymphoblastic leukemia
KW - Philadelphia chromosome
KW - additional cytogenetic alterations
KW - monosomies
KW - prognosis
U2 - 10.1080/10428194.2017.1326596
DO - 10.1080/10428194.2017.1326596
M3 - Article
C2 - 28554259
SN - 1042-8194
VL - 59
SP - 146
EP - 154
JO - Leukemia and Lymphoma
JF - Leukemia and Lymphoma
IS - 1
ER -