TY - JOUR
T1 - First enantioselective synthesis of (-)-(Z)-2,3-methano-L-glutamic acid
AU - Jiménez, José M.
AU - Ortuño, Rosa M.
PY - 1996/11/8
Y1 - 1996/11/8
N2 - (-)-(Z)-2,3-Methano-L-glutamic acid, a potential mGluR agonist, has been synthesized for the first time in 40% overall yield from a homochiral amino pentenoate as an easily available precursor. A conveniently protected (-)-(Z)-cyclo-aspartic acid derivative was the key intermediate, homologation of the carboxylic acid having been accomplished via the Arndt-Eistert procedure. Copyright (C) Elsevier Science Ltd.
AB - (-)-(Z)-2,3-Methano-L-glutamic acid, a potential mGluR agonist, has been synthesized for the first time in 40% overall yield from a homochiral amino pentenoate as an easily available precursor. A conveniently protected (-)-(Z)-cyclo-aspartic acid derivative was the key intermediate, homologation of the carboxylic acid having been accomplished via the Arndt-Eistert procedure. Copyright (C) Elsevier Science Ltd.
U2 - 10.1016/0957-4166(96)00423-5
DO - 10.1016/0957-4166(96)00423-5
M3 - Article
SN - 0957-4166
VL - 7
SP - 3203
EP - 3208
JO - Tetrahedron Asymmetry
JF - Tetrahedron Asymmetry
IS - 11
ER -