Evaluation of the disinfectant effect of Solprogel against human immunodeficiency virus type 1 (HIV-1)

A. Hernández; F. J. Belda; J. Domínguez; M. Gimenez; M. Caraballo; C. Ramil; V. Ausina; Juana Maria Lourdes Matas Andreu

doi:10.1016/S0195-6701(96)90070-5

Evaluation of the disinfectant effect of Solprogel against human immunodeficiency virus type 1 (HIV-1)

A. Hernández, F. J. Belda, J. Domínguez, M. Gimenez, M. Caraballo, C. Ramil, V. Ausina, Juana Maria Lourdes Matas Andreu

Departament de Genètica i de Microbiologia

Producció científica: Contribució a revista › Article › Recerca › Avaluat per experts

2 Cites (Scopus)

Resum

The antiviral activities of sodium dichloroisocyanurate (NaDCC) and a commercial product (Solprogel 2%) against human immunodeficiency virus type 1 (HIV-1) were investigated using a quantitative suspension test method. Solprogel is a compound that contains NaDCC and a biodegradable polymer of acrylic acid. Viral suspensions were prepared containing 3.2 x 106 tissue culture infective dose 50 (TCID50) in culture media. Syncytium formation in the MT-2 line and HIV antigen p24 on the supernatant of the cultures were used to determine viral titre. Results indicate that satisfactory disinfection (1000-fold reduction in 5 min) can be achieved using NaDCC and Solprogel at concentrations of 100 and 120ppm available chlorine, respectively.

Idioma original	Anglès
Pàgines (de-a)	223-228
Revista	Journal of Hospital Infection
Volum	34
DOIs	https://doi.org/10.1016/S0195-6701(96)90070-5
Estat de la publicació	Publicada - 1 de gen. 1996

SDG de les Nacions Unides

Aquest resultat contribueix als següents objectius de desenvolupament sostenible.

Accés al document

10.1016/S0195-6701(96)90070-5

Com citar-ho

@article{efca39b2559d44428cc34ed1942c80bb,

title = "Evaluation of the disinfectant effect of Solprogel against human immunodeficiency virus type 1 (HIV-1)",

abstract = "The antiviral activities of sodium dichloroisocyanurate (NaDCC) and a commercial product (Solprogel 2%) against human immunodeficiency virus type 1 (HIV-1) were investigated using a quantitative suspension test method. Solprogel is a compound that contains NaDCC and a biodegradable polymer of acrylic acid. Viral suspensions were prepared containing 3.2 x 106 tissue culture infective dose 50 (TCID50) in culture media. Syncytium formation in the MT-2 line and HIV antigen p24 on the supernatant of the cultures were used to determine viral titre. Results indicate that satisfactory disinfection (1000-fold reduction in 5 min) can be achieved using NaDCC and Solprogel at concentrations of 100 and 120ppm available chlorine, respectively.",

keywords = "Disinfectant granules, HIV, Sodium dichloroisocyanurate, Solprogel",

author = "A. Hern{\'a}ndez and Belda, {F. J.} and J. Dom{\'i}nguez and M. Gimenez and M. Caraballo and C. Ramil and V. Ausina and {Matas Andreu}, {Juana Maria Lourdes}",

year = "1996",

month = jan,

day = "1",

doi = "10.1016/S0195-6701(96)90070-5",

language = "English",

volume = "34",

pages = "223--228",

journal = "Journal of Hospital Infection",

issn = "0195-6701",

publisher = "W.B. Saunders Ltd",

}

TY - JOUR

T1 - Evaluation of the disinfectant effect of Solprogel against human immunodeficiency virus type 1 (HIV-1)

AU - Hernández, A.

AU - Belda, F. J.

AU - Domínguez, J.

AU - Gimenez, M.

AU - Caraballo, M.

AU - Ramil, C.

AU - Ausina, V.

AU - Matas Andreu, Juana Maria Lourdes

PY - 1996/1/1

Y1 - 1996/1/1

N2 - The antiviral activities of sodium dichloroisocyanurate (NaDCC) and a commercial product (Solprogel 2%) against human immunodeficiency virus type 1 (HIV-1) were investigated using a quantitative suspension test method. Solprogel is a compound that contains NaDCC and a biodegradable polymer of acrylic acid. Viral suspensions were prepared containing 3.2 x 106 tissue culture infective dose 50 (TCID50) in culture media. Syncytium formation in the MT-2 line and HIV antigen p24 on the supernatant of the cultures were used to determine viral titre. Results indicate that satisfactory disinfection (1000-fold reduction in 5 min) can be achieved using NaDCC and Solprogel at concentrations of 100 and 120ppm available chlorine, respectively.

AB - The antiviral activities of sodium dichloroisocyanurate (NaDCC) and a commercial product (Solprogel 2%) against human immunodeficiency virus type 1 (HIV-1) were investigated using a quantitative suspension test method. Solprogel is a compound that contains NaDCC and a biodegradable polymer of acrylic acid. Viral suspensions were prepared containing 3.2 x 106 tissue culture infective dose 50 (TCID50) in culture media. Syncytium formation in the MT-2 line and HIV antigen p24 on the supernatant of the cultures were used to determine viral titre. Results indicate that satisfactory disinfection (1000-fold reduction in 5 min) can be achieved using NaDCC and Solprogel at concentrations of 100 and 120ppm available chlorine, respectively.

KW - Disinfectant granules

KW - HIV

KW - Sodium dichloroisocyanurate

KW - Solprogel

U2 - 10.1016/S0195-6701(96)90070-5

DO - 10.1016/S0195-6701(96)90070-5

M3 - Article

SN - 0195-6701

VL - 34

SP - 223

EP - 228

JO - Journal of Hospital Infection

JF - Journal of Hospital Infection

ER -

Evaluation of the disinfectant effect of Solprogel against human immunodeficiency virus type 1 (HIV-1)

Resum

SDG de les Nacions Unides

Accés al document

Fingerprint

Com citar-ho