Evaluation of Candidate Genes Related to Neuronal Apoptosis in Late-Onset Alzheimer's Disease

S Moreno-Grau; B Barneda; P Carriba; J Marín; O Sotolongo-Grau; I Hernández; M Rosende-Roca; A Mauleón; L Vargas; A Espinosa; M Alegret; O Rodriguez; G Ortega; MV Fernández; J López-Arrieta; L Tárraga; M Boada; C Antúnez; J López; A Ruiz; Joan Xavier Comella Carnice

doi:10.3233/JAD-142721

Evaluation of Candidate Genes Related to Neuronal Apoptosis in Late-Onset Alzheimer's Disease

S Moreno-Grau, B Barneda, P Carriba, J Marín, O Sotolongo-Grau, I Hernández, M Rosende-Roca, A Mauleón, L Vargas, A Espinosa, M Alegret, O Rodriguez, G Ortega, MV Fernández, J López-Arrieta, L Tárraga, M Boada, C Antúnez, J López, A RuizJoan Xavier Comella Carnice

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© 2015 - IOS Press and the authors. All rights reserved. The objective of this study was to identify genetic variation in genes encoding death receptors and signals that modulate their activity. After conducting a meta-analysis with five previous genome-wide association studies and aggregated data, the most significant signals, (TNF locus: rs2395488, rs2534672, and rs9267445; and FASLG locus: rs730278), were replicated in 1,046 cases and 372 controls. The rs2395488 and rs2534672 markers showed a modest protective effect (OR = 0.849, p = 0.49780; OR = 0.687, p = 0.11335), in contrast to rs730278 marker (OR = 1.146, p = 0.17212), which did not follow the previous effect direction; in any case it reached the significance level. Final meta-analysis, adding the replication sample, confirmed these observations. We concluded that FASLG marker is not etiologically linked to Alzheimer's disease. However, single nucleotide polymorphisms around TNF locus require further analyses in order to explain the association between Alzheimer's disease and human leukocyte antigen.

Idioma original	Anglès
Pàgines (de-a)	621-629
Revista	Journal of Alzheimer's Disease
Volum	45
Número	2
DOIs	https://doi.org/10.3233/JAD-142721
Estat de la publicació	Publicada - 1 de gen. 2015

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10.3233/JAD-142721

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https://www.scopus.com/pages/publications/84925344528

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Moreno-Grau, S., Barneda, B., Carriba, P., Marín, J., Sotolongo-Grau, O., Hernández, I., Rosende-Roca, M., Mauleón, A., Vargas, L., Espinosa, A., Alegret, M., Rodriguez, O., Ortega, G., Fernández, MV., López-Arrieta, J., Tárraga, L., Boada, M., Antúnez, C., López, J., ... Comella Carnice, J. X. (2015). Evaluation of Candidate Genes Related to Neuronal Apoptosis in Late-Onset Alzheimer's Disease. Journal of Alzheimer's Disease, 45(2), 621-629. https://doi.org/10.3233/JAD-142721

@article{e4c9e7d9f5cf4f3c93bf94b0a9f23f40,

title = "Evaluation of Candidate Genes Related to Neuronal Apoptosis in Late-Onset Alzheimer's Disease",

abstract = "{\textcopyright} 2015 - IOS Press and the authors. All rights reserved. The objective of this study was to identify genetic variation in genes encoding death receptors and signals that modulate their activity. After conducting a meta-analysis with five previous genome-wide association studies and aggregated data, the most significant signals, (TNF locus: rs2395488, rs2534672, and rs9267445; and FASLG locus: rs730278), were replicated in 1,046 cases and 372 controls. The rs2395488 and rs2534672 markers showed a modest protective effect (OR = 0.849, p = 0.49780; OR = 0.687, p = 0.11335), in contrast to rs730278 marker (OR = 1.146, p = 0.17212), which did not follow the previous effect direction; in any case it reached the significance level. Final meta-analysis, adding the replication sample, confirmed these observations. We concluded that FASLG marker is not etiologically linked to Alzheimer's disease. However, single nucleotide polymorphisms around TNF locus require further analyses in order to explain the association between Alzheimer's disease and human leukocyte antigen.",

keywords = "Alzheimer's disease, FASLG, TNF, apoptosis, death receptors, genetics, genome-wide association study, meta-analysis",

author = "S Moreno-Grau and B Barneda and P Carriba and J Mar{\'i}n and O Sotolongo-Grau and I Hern{\'a}ndez and M Rosende-Roca and A Maule{\'o}n and L Vargas and A Espinosa and M Alegret and O Rodriguez and G Ortega and MV Fern{\'a}ndez and J L{\'o}pez-Arrieta and L T{\'a}rraga and M Boada and C Ant{\'u}nez and J L{\'o}pez and A Ruiz and \{Comella Carnice\}, \{Joan Xavier\}",

year = "2015",

month = jan,

day = "1",

doi = "10.3233/JAD-142721",

language = "English",

volume = "45",

pages = "621--629",

journal = "Journal of Alzheimer's Disease",

issn = "1387-2877",

publisher = "SAGE Publications Ltd",

number = "2",

}

Moreno-Grau, S, Barneda, B, Carriba, P, Marín, J, Sotolongo-Grau, O, Hernández, I, Rosende-Roca, M, Mauleón, A, Vargas, L, Espinosa, A, Alegret, M, Rodriguez, O, Ortega, G, Fernández, MV, López-Arrieta, J, Tárraga, L, Boada, M, Antúnez, C, López, J, Ruiz, A & Comella Carnice, JX 2015, 'Evaluation of Candidate Genes Related to Neuronal Apoptosis in Late-Onset Alzheimer's Disease', Journal of Alzheimer's Disease, vol. 45, núm. 2, pàg. 621-629. https://doi.org/10.3233/JAD-142721

TY - JOUR

T1 - Evaluation of Candidate Genes Related to Neuronal Apoptosis in Late-Onset Alzheimer's Disease

AU - Moreno-Grau, S

AU - Barneda, B

AU - Carriba, P

AU - Marín, J

AU - Sotolongo-Grau, O

AU - Hernández, I

AU - Rosende-Roca, M

AU - Mauleón, A

AU - Vargas, L

AU - Espinosa, A

AU - Alegret, M

AU - Rodriguez, O

AU - Ortega, G

AU - Fernández, MV

AU - López-Arrieta, J

AU - Tárraga, L

AU - Boada, M

AU - Antúnez, C

AU - López, J

AU - Ruiz, A

AU - Comella Carnice, Joan Xavier

PY - 2015/1/1

Y1 - 2015/1/1

N2 - © 2015 - IOS Press and the authors. All rights reserved. The objective of this study was to identify genetic variation in genes encoding death receptors and signals that modulate their activity. After conducting a meta-analysis with five previous genome-wide association studies and aggregated data, the most significant signals, (TNF locus: rs2395488, rs2534672, and rs9267445; and FASLG locus: rs730278), were replicated in 1,046 cases and 372 controls. The rs2395488 and rs2534672 markers showed a modest protective effect (OR = 0.849, p = 0.49780; OR = 0.687, p = 0.11335), in contrast to rs730278 marker (OR = 1.146, p = 0.17212), which did not follow the previous effect direction; in any case it reached the significance level. Final meta-analysis, adding the replication sample, confirmed these observations. We concluded that FASLG marker is not etiologically linked to Alzheimer's disease. However, single nucleotide polymorphisms around TNF locus require further analyses in order to explain the association between Alzheimer's disease and human leukocyte antigen.

AB - © 2015 - IOS Press and the authors. All rights reserved. The objective of this study was to identify genetic variation in genes encoding death receptors and signals that modulate their activity. After conducting a meta-analysis with five previous genome-wide association studies and aggregated data, the most significant signals, (TNF locus: rs2395488, rs2534672, and rs9267445; and FASLG locus: rs730278), were replicated in 1,046 cases and 372 controls. The rs2395488 and rs2534672 markers showed a modest protective effect (OR = 0.849, p = 0.49780; OR = 0.687, p = 0.11335), in contrast to rs730278 marker (OR = 1.146, p = 0.17212), which did not follow the previous effect direction; in any case it reached the significance level. Final meta-analysis, adding the replication sample, confirmed these observations. We concluded that FASLG marker is not etiologically linked to Alzheimer's disease. However, single nucleotide polymorphisms around TNF locus require further analyses in order to explain the association between Alzheimer's disease and human leukocyte antigen.

KW - Alzheimer's disease

KW - FASLG

KW - TNF

KW - apoptosis

KW - death receptors

KW - genetics

KW - genome-wide association study

KW - meta-analysis

UR - https://www.scopus.com/pages/publications/84925344528

U2 - 10.3233/JAD-142721

DO - 10.3233/JAD-142721

M3 - Article

SN - 1387-2877

VL - 45

SP - 621

EP - 629

JO - Journal of Alzheimer's Disease

JF - Journal of Alzheimer's Disease

IS - 2

ER -

Evaluation of Candidate Genes Related to Neuronal Apoptosis in Late-Onset Alzheimer's Disease

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