ETV6/RUNX1 rearrangement in childhood B-precursor acute lymphoblastic leukemia with normal karyotypes or without cytogenetic results

Y. Alvarez; S. Gaitán; A. Perez; P. Bastida; J. J. Ortega; N. Dastugue; A. Robert; A. Aventín; I. Badell; M. Guitart; M. Melo; M. R. Caballín; M. D. Coll

doi:10.1016/j.cancergencyto.2003.10.012

ETV6/RUNX1 rearrangement in childhood B-precursor acute lymphoblastic leukemia with normal karyotypes or without cytogenetic results

Y. Alvarez, S. Gaitán, A. Perez, P. Bastida, J. J. Ortega, N. Dastugue, A. Robert, A. Aventín, I. Badell, M. Guitart, M. Melo, M. R. Caballín, M. D. Coll

Producció científica: Contribució a revista › Article › Recerca › Avaluat per experts

4 Cites (Scopus)

Resum

The ETV6/RUNX1 rearrangement (also known as TEL/AML1) was evaluated in 39 children with B-precursor acute lymphoblastic leukemia (ALL) who had a normal karyotype or lack of mitoses. Forty-one point six percent of patients with normal karyotypes and 66.6% of patients without mitoses presented with the ETV6/RUNX1 rearrangement. In addition to this rearrangement, eight patients showed loss of the normal ETV6 allele; of three patients without mitoses, two showed an extra signal of the RUNX1 gene and the third showed the fusion gene duplicated and loss of the normal ETV6 allele. One patient without the ETV6/RUNX1 rearrangement and without mitoses showed two extra signals of the RUNX1 gene. © 2004 Elsevier Inc. All rights reserved.

Idioma original	Anglès
Pàgines (de-a)	77-80
Revista	Cancer Genetics and Cytogenetics
Volum	152
DOIs	https://doi.org/10.1016/j.cancergencyto.2003.10.012
Estat de la publicació	Publicada - 1 de jul. 2004

Accés al document

10.1016/j.cancergencyto.2003.10.012

Com citar-ho

Alvarez, Y., Gaitán, S., Perez, A., Bastida, P., Ortega, J. J., Dastugue, N., Robert, A., Aventín, A., Badell, I., Guitart, M., Melo, M., Caballín, M. R., & Coll, M. D. (2004). ETV6/RUNX1 rearrangement in childhood B-precursor acute lymphoblastic leukemia with normal karyotypes or without cytogenetic results. Cancer Genetics and Cytogenetics, 152, 77-80. https://doi.org/10.1016/j.cancergencyto.2003.10.012

@article{de3224d5edf54b828256a36a0a4d2991,

title = "ETV6/RUNX1 rearrangement in childhood B-precursor acute lymphoblastic leukemia with normal karyotypes or without cytogenetic results",

abstract = "The ETV6/RUNX1 rearrangement (also known as TEL/AML1) was evaluated in 39 children with B-precursor acute lymphoblastic leukemia (ALL) who had a normal karyotype or lack of mitoses. Forty-one point six percent of patients with normal karyotypes and 66.6% of patients without mitoses presented with the ETV6/RUNX1 rearrangement. In addition to this rearrangement, eight patients showed loss of the normal ETV6 allele; of three patients without mitoses, two showed an extra signal of the RUNX1 gene and the third showed the fusion gene duplicated and loss of the normal ETV6 allele. One patient without the ETV6/RUNX1 rearrangement and without mitoses showed two extra signals of the RUNX1 gene. {\textcopyright} 2004 Elsevier Inc. All rights reserved.",

author = "Y. Alvarez and S. Gait{\'a}n and A. Perez and P. Bastida and Ortega, {J. J.} and N. Dastugue and A. Robert and A. Avent{\'i}n and I. Badell and M. Guitart and M. Melo and Caball{\'i}n, {M. R.} and Coll, {M. D.}",

year = "2004",

month = jul,

day = "1",

doi = "10.1016/j.cancergencyto.2003.10.012",

language = "English",

volume = "152",

pages = "77--80",

}

Alvarez, Y, Gaitán, S, Perez, A, Bastida, P, Ortega, JJ, Dastugue, N, Robert, A, Aventín, A, Badell, I, Guitart, M, Melo, M, Caballín, MR & Coll, MD 2004, 'ETV6/RUNX1 rearrangement in childhood B-precursor acute lymphoblastic leukemia with normal karyotypes or without cytogenetic results', Cancer Genetics and Cytogenetics, vol. 152, pàg. 77-80. https://doi.org/10.1016/j.cancergencyto.2003.10.012

TY - JOUR

T1 - ETV6/RUNX1 rearrangement in childhood B-precursor acute lymphoblastic leukemia with normal karyotypes or without cytogenetic results

AU - Alvarez, Y.

AU - Gaitán, S.

AU - Perez, A.

AU - Bastida, P.

AU - Ortega, J. J.

AU - Dastugue, N.

AU - Robert, A.

AU - Aventín, A.

AU - Badell, I.

AU - Guitart, M.

AU - Melo, M.

AU - Caballín, M. R.

AU - Coll, M. D.

PY - 2004/7/1

Y1 - 2004/7/1

N2 - The ETV6/RUNX1 rearrangement (also known as TEL/AML1) was evaluated in 39 children with B-precursor acute lymphoblastic leukemia (ALL) who had a normal karyotype or lack of mitoses. Forty-one point six percent of patients with normal karyotypes and 66.6% of patients without mitoses presented with the ETV6/RUNX1 rearrangement. In addition to this rearrangement, eight patients showed loss of the normal ETV6 allele; of three patients without mitoses, two showed an extra signal of the RUNX1 gene and the third showed the fusion gene duplicated and loss of the normal ETV6 allele. One patient without the ETV6/RUNX1 rearrangement and without mitoses showed two extra signals of the RUNX1 gene. © 2004 Elsevier Inc. All rights reserved.

AB - The ETV6/RUNX1 rearrangement (also known as TEL/AML1) was evaluated in 39 children with B-precursor acute lymphoblastic leukemia (ALL) who had a normal karyotype or lack of mitoses. Forty-one point six percent of patients with normal karyotypes and 66.6% of patients without mitoses presented with the ETV6/RUNX1 rearrangement. In addition to this rearrangement, eight patients showed loss of the normal ETV6 allele; of three patients without mitoses, two showed an extra signal of the RUNX1 gene and the third showed the fusion gene duplicated and loss of the normal ETV6 allele. One patient without the ETV6/RUNX1 rearrangement and without mitoses showed two extra signals of the RUNX1 gene. © 2004 Elsevier Inc. All rights reserved.

U2 - 10.1016/j.cancergencyto.2003.10.012

DO - 10.1016/j.cancergencyto.2003.10.012

M3 - Article

SN - 0165-4608

VL - 152

SP - 77

EP - 80

JO - Cancer Genetics and Cytogenetics

JF - Cancer Genetics and Cytogenetics

ER -

ETV6/RUNX1 rearrangement in childhood B-precursor acute lymphoblastic leukemia with normal karyotypes or without cytogenetic results

Resum

Accés al document

Fingerprint

Com citar-ho