TY - JOUR
T1 - Enzyme-Powered Porous Micromotors Built from a Hierarchical Micro- And Mesoporous UiO-Type Metal-Organic Framework
AU - Yang, Yunhui
AU - Arqué, Xavier
AU - Patiño, Tania
AU - Guillerm, Vincent
AU - Blersch, Pascal Raphael
AU - Pérez-Carvajal, Javier
AU - Imaz, Inhar
AU - Maspoch Comamala, Daniel
AU - Sánchez Ordóñez, Samuel
PY - 2020
Y1 - 2020
N2 - Here, we report the design, synthesis, and functional testing of enzyme-powered porous micromotors built from a metal-organic framework (MOF). We began by subjecting a presynthesized microporous UiO-type MOF to ozonolysis, to confer it with mesopores sufficiently large to adsorb and host the enzyme catalase (size: 6-10 nm). We then encapsulated catalase inside the mesopores, observing that they are hosted in those mesopores located at the subsurface of the MOF crystals. In the presence of H2O2 fuel, MOF motors (or MOFtors) exhibit jet-like propulsion enabled by enzymatic generation of oxygen bubbles. Moreover, thanks to their hierarchical pore system, the MOFtors retain sufficient free space for adsorption of additional targeted species, which we validated by testing a MOFtor for removal of rhodamine B during self-propulsion.
AB - Here, we report the design, synthesis, and functional testing of enzyme-powered porous micromotors built from a metal-organic framework (MOF). We began by subjecting a presynthesized microporous UiO-type MOF to ozonolysis, to confer it with mesopores sufficiently large to adsorb and host the enzyme catalase (size: 6-10 nm). We then encapsulated catalase inside the mesopores, observing that they are hosted in those mesopores located at the subsurface of the MOF crystals. In the presence of H2O2 fuel, MOF motors (or MOFtors) exhibit jet-like propulsion enabled by enzymatic generation of oxygen bubbles. Moreover, thanks to their hierarchical pore system, the MOFtors retain sufficient free space for adsorption of additional targeted species, which we validated by testing a MOFtor for removal of rhodamine B during self-propulsion.
KW - Enzymatic generation
KW - Enzyme catalase
KW - Free spaces
KW - Functional testing
KW - Hierarchical pore systems
KW - Microporous
KW - Oxygen bubbles
KW - Self propulsion
KW - Biocatalysis
KW - Catalase
KW - Metal-Organic Frameworks
KW - Porosity
U2 - 10.1021/jacs.0c11061
DO - 10.1021/jacs.0c11061
M3 - Article
SN - 0002-7863
VL - 142
SP - 20962
EP - 20967
JO - Journal of the American Chemical Society
JF - Journal of the American Chemical Society
IS - 50
ER -