TY - JOUR
T1 - Enterovirus D68 in Hospitalized Children, Barcelona, Spain, 2014-2021
AU - Andres, Cristina
AU - Vila, Jorgina
AU - Creus-Costa, Anna
AU - Pinana, Maria
AU - Gonzalez-Sanchez, Alejandra
AU - Esperalba, Juliana
AU - Codina, Maria Gema
AU - Castillo, Carla
AU - Martin, Maria Carmen
AU - Fuentes, Francisco
AU - Rubio, Susana
AU - Garcia-Comunas, Karen
AU - Vasquez-Mercado, Rodrigo
AU - Saubi, Narcis
AU - Rodrigo, Carlos
AU - Pumarola, Tomas
AU - Anton, Andres
N1 - Publisher Copyright:
© 2022 Centers for Disease Control and Prevention (CDC). All rights reserved.
PY - 2022/7
Y1 - 2022/7
N2 - To determine molecular epidemiology and clinical features of enterovirus D68 (EV-D68) infections, we reviewed EV-D68-associated respiratory cases at a hospital in Barcelona, Spain, during 2014-2021. Respiratory samples were collected from hospitalized patients or outpatients with symptoms of acute respiratory tract infection or suggestive of enterovirus infection. Enterovirus detection was performed by real-time multiplex reverse transcription PCR and characterization by phylogenetic analysis of the partial viral protein 1 coding region sequences. From 184 patients with EV-D68 infection, circulating subclades were B3 (80%), D1 (17%), B2 (1%), and A (<1%); clade proportions shifted over time. EV-D68 was detected mostly in children (86%) and biennially (2016, 2018, 2021). In patients <16 years of age, the most common sign/symptom was lower respiratory tract infection, for which 11.8% required pediatric intensive care unit admission and 2.3% required invasive mechanical ventilation; neurologic complications developed in 1. The potential neurotropism indicates that enterovirus surveillance should be mandatory.
AB - To determine molecular epidemiology and clinical features of enterovirus D68 (EV-D68) infections, we reviewed EV-D68-associated respiratory cases at a hospital in Barcelona, Spain, during 2014-2021. Respiratory samples were collected from hospitalized patients or outpatients with symptoms of acute respiratory tract infection or suggestive of enterovirus infection. Enterovirus detection was performed by real-time multiplex reverse transcription PCR and characterization by phylogenetic analysis of the partial viral protein 1 coding region sequences. From 184 patients with EV-D68 infection, circulating subclades were B3 (80%), D1 (17%), B2 (1%), and A (<1%); clade proportions shifted over time. EV-D68 was detected mostly in children (86%) and biennially (2016, 2018, 2021). In patients <16 years of age, the most common sign/symptom was lower respiratory tract infection, for which 11.8% required pediatric intensive care unit admission and 2.3% required invasive mechanical ventilation; neurologic complications developed in 1. The potential neurotropism indicates that enterovirus surveillance should be mandatory.
UR - http://www.scopus.com/inward/record.url?scp=85133101261&partnerID=8YFLogxK
U2 - 10.3201/eid2807.220264
DO - 10.3201/eid2807.220264
M3 - Article
C2 - 35731133
AN - SCOPUS:85133101261
SN - 1080-6040
VL - 28
SP - 1327
EP - 1331
JO - Emerging Infectious Diseases
JF - Emerging Infectious Diseases
IS - 7
ER -