Enhanced terahertz sensitivity for glucose detection with a hydrogel platform embedded with Au nanoparticles

Jingjing Zhao; Shaohua Lu; Julio Bastos-Arrieta; Cristina Palet; Yiling Sun; Renheng Wang; Zhengfang Qian; Shuting Fan

doi:10.1364/BOE.461414

Enhanced terahertz sensitivity for glucose detection with a hydrogel platform embedded with Au nanoparticles

Jingjing Zhao, Shaohua Lu, Julio Bastos-Arrieta, Cristina Palet, Yiling Sun, Renheng Wang, Zhengfang Qian, Shuting Fan^*

^*Autor corresponent d’aquest treball

Shenzhen University

Producció científica: Contribució a una revista › Article › Recerca › Avaluat per experts

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Resum

We presented a strategy for enhancing the sensitivity of terahertz glucose sensing with a hydrogel platform pre-embedded with Au nanoparticles. Physiological-level glucose solutions ranging from 0 to 0.8 mg/mL were measured and the extracted absorption coefficients can be clearly distinguished compared to traditional terahertz time domain spectroscopy performed directly on aqueous solutions. Further, Isotherm models were applied to successfully describe the relationship between the absorption coefficient and the glucose concentration (R² = 0.9977). Finally, the origin of the sensitivity enhancement was investigated and verified to be the pH change induced by the catalysis of Au nanoparticles to glucose oxidation.

Idioma original	English
Pàgines (de-a)	4021-4031
Nombre de pàgines	11
Revista	Biomedical Optics Express
Volum	13
Número	7
DOIs	https://doi.org/10.1364/BOE.461414
Estat de la publicació	Publicada - 1 de jul. 2022

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Enhanced terahertz sensitivity for glucose detection with a hydrogel platform embedded with Au nanoparticles
Zhao, J. (Creador), Lu, S. (Creador), Bastos-Arrieta, J. (Creador), Palet, C. (Creador), Sun, Y. (Creador), Wang, R. (Creador), Qian, Z. (Creador) & Fan, S. (Creador), Optica Publishing Group, 22 de juny 2022
DOI: 10.6084/m9.figshare.c.6047105.v2, https://opticapublishing.figshare.com/collections/Enhanced_terahertz_sensitivity_for_glucose_detection_with_a_hydrogel_platform_embedded_with_Au_nanoparticles/6047105/2 i un enllaç més, https://opticapublishing.figshare.com/collections/Enhanced_terahertz_sensitivity_for_glucose_detection_with_a_hydrogel_platform_embedded_with_Au_nanoparticles/6047105/1 (mostra’n menys)
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title = "Enhanced terahertz sensitivity for glucose detection with a hydrogel platform embedded with Au nanoparticles",

abstract = "We presented a strategy for enhancing the sensitivity of terahertz glucose sensing with a hydrogel platform pre-embedded with Au nanoparticles. Physiological-level glucose solutions ranging from 0 to 0.8 mg/mL were measured and the extracted absorption coefficients can be clearly distinguished compared to traditional terahertz time domain spectroscopy performed directly on aqueous solutions. Further, Isotherm models were applied to successfully describe the relationship between the absorption coefficient and the glucose concentration (R2 = 0.9977). Finally, the origin of the sensitivity enhancement was investigated and verified to be the pH change induced by the catalysis of Au nanoparticles to glucose oxidation.",

keywords = "teraHertz (THz), glucose sensing, hydrogel platform, Au nanoparticles",

author = "Jingjing Zhao and Shaohua Lu and Julio Bastos-Arrieta and Cristina Palet and Yiling Sun and Renheng Wang and Zhengfang Qian and Shuting Fan",

note = "Funding Information: Funding. National Natural Science Foundation of China (61805150); Natural Science Foundation of Guangdong Province (2021A1515012296); Key Technologies Research and Development Program (2019YFB2204500); Shenzhen Science and Technology Innovation Program (KQTD20180412181422399); Science, Technology and Innovation Commission of Shenzhen Municipality (JCYJ20180507181858539). Publisher Copyright: {\textcopyright} 2022 Optica Publishing Group under the terms of the Optica Open Access Publishing Agreement",

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doi = "10.1364/BOE.461414",

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AU - Zhao, Jingjing

AU - Lu, Shaohua

AU - Bastos-Arrieta, Julio

AU - Palet, Cristina

AU - Sun, Yiling

AU - Wang, Renheng

AU - Qian, Zhengfang

AU - Fan, Shuting

N1 - Funding Information: Funding. National Natural Science Foundation of China (61805150); Natural Science Foundation of Guangdong Province (2021A1515012296); Key Technologies Research and Development Program (2019YFB2204500); Shenzhen Science and Technology Innovation Program (KQTD20180412181422399); Science, Technology and Innovation Commission of Shenzhen Municipality (JCYJ20180507181858539). Publisher Copyright: © 2022 Optica Publishing Group under the terms of the Optica Open Access Publishing Agreement

PY - 2022/7/1

Y1 - 2022/7/1

N2 - We presented a strategy for enhancing the sensitivity of terahertz glucose sensing with a hydrogel platform pre-embedded with Au nanoparticles. Physiological-level glucose solutions ranging from 0 to 0.8 mg/mL were measured and the extracted absorption coefficients can be clearly distinguished compared to traditional terahertz time domain spectroscopy performed directly on aqueous solutions. Further, Isotherm models were applied to successfully describe the relationship between the absorption coefficient and the glucose concentration (R2 = 0.9977). Finally, the origin of the sensitivity enhancement was investigated and verified to be the pH change induced by the catalysis of Au nanoparticles to glucose oxidation.

AB - We presented a strategy for enhancing the sensitivity of terahertz glucose sensing with a hydrogel platform pre-embedded with Au nanoparticles. Physiological-level glucose solutions ranging from 0 to 0.8 mg/mL were measured and the extracted absorption coefficients can be clearly distinguished compared to traditional terahertz time domain spectroscopy performed directly on aqueous solutions. Further, Isotherm models were applied to successfully describe the relationship between the absorption coefficient and the glucose concentration (R2 = 0.9977). Finally, the origin of the sensitivity enhancement was investigated and verified to be the pH change induced by the catalysis of Au nanoparticles to glucose oxidation.

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KW - glucose sensing

KW - hydrogel platform

KW - Au nanoparticles

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SN - 2156-7085

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Enhanced terahertz sensitivity for glucose detection with a hydrogel platform embedded with Au nanoparticles

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Enhanced terahertz sensitivity for glucose detection with a hydrogel platform embedded with Au nanoparticles

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