TY - JOUR
T1 - Enhanced host-guest electrochemical recognition of dopamine using cyclodextrin in the presence of carbon nanotubes
AU - Alarcón-Angeles, G.
AU - Pérez-López, B.
AU - Palomar-Pardave, M.
AU - Ramírez-Silva, M. T.
AU - Alegret, S.
AU - Merkoçi, A.
PY - 2008/5/1
Y1 - 2008/5/1
N2 - A novel application of multiwall carbon nanotubes (MWCNT) for biosensor use is presented. β-Cyclodextrin (β-CD) as molecular receptor and MWCNT as enhancer of electron transfer are integrated in a dopamine (DA) electrochemical sensor system. The proposed molecular host-guest recognition based sensor has a high electrochemical sensitivity for the determination of DA. The electrochemical behaviour of DA is investigated by cyclic voltammetry (CV). The response mechanism of the MWCNT/β-CD modified electrode for DA is based on the combination of electrostatic and inclusion interaction of β-CD with DA which is distinguished from the response mechanism of non-modified electrode. The proposed integrated sensor showed improved analytical performance characteristics in catalytic oxidation of DA compared with non-modified electrode: excellent sensitivity, repeatability, stability, selectivity and recovery for the determination of DA. Under optimized conditions linear calibration plots were obtained for amperometric detection of DA over the range 0.01-0.08 mM. © 2008 Elsevier Ltd. All rights reserved.
AB - A novel application of multiwall carbon nanotubes (MWCNT) for biosensor use is presented. β-Cyclodextrin (β-CD) as molecular receptor and MWCNT as enhancer of electron transfer are integrated in a dopamine (DA) electrochemical sensor system. The proposed molecular host-guest recognition based sensor has a high electrochemical sensitivity for the determination of DA. The electrochemical behaviour of DA is investigated by cyclic voltammetry (CV). The response mechanism of the MWCNT/β-CD modified electrode for DA is based on the combination of electrostatic and inclusion interaction of β-CD with DA which is distinguished from the response mechanism of non-modified electrode. The proposed integrated sensor showed improved analytical performance characteristics in catalytic oxidation of DA compared with non-modified electrode: excellent sensitivity, repeatability, stability, selectivity and recovery for the determination of DA. Under optimized conditions linear calibration plots were obtained for amperometric detection of DA over the range 0.01-0.08 mM. © 2008 Elsevier Ltd. All rights reserved.
UR - https://www.scopus.com/pages/publications/43049092626
U2 - 10.1016/j.carbon.2008.02.025
DO - 10.1016/j.carbon.2008.02.025
M3 - Article
SN - 0008-6223
VL - 46
SP - 898
EP - 906
JO - Carbon
JF - Carbon
IS - 6
ER -