Endogenous mechanisms of neuroprotection: To boost or not to boost

Sara Marmolejo‐Martínez‐Artesero; Caty Casas; David Romeo‐Guitart

doi:10.3390/cells10020370

Endogenous mechanisms of neuroprotection: To boost or not to boost

Sara Marmolejo‐Martínez‐Artesero, Caty Casas, David Romeo‐Guitart

Producció científica: Contribució a revista › Article de revisió › Recerca › Avaluat per experts

23 Cites (Scopus)

Resum

Les cèl·lules postmitòtiques, com les neurones, han de viure tota la vida. Per aquest motiu, els organismes/cèl·lules han desenvolupat mecanismes d'autoreparació que permeten una llarga vida. El flux de treball en el descobriment dels neuroprotectors durant els últims anys s'ha centrat a bloquejar els mecanismes fisiopatològics que condueixen a la pèrdua neuronal en la neurodegeneració. Malauradament, només unes quantes estratègies d'aquests estudis han aconseguit alentir o prevenir la neurodegeneració. Hi ha proves convincents que demostren que l'afirmació dels mecanismes d'autoreparació que els organismes/cèl·lules tenen de manera endògena, coneguts comunament com resiliència cel·lular, pot enfortir les neurones i promoure-ne l'autoreparació. Tot i que encara no s'ha prestat prou atenció a la potenciació d'aquests mecanismes, aquestes vies obren noves avingudes terapèutiques per prevenir la mort neuronal i millorar la neurodegeneració. En aquest sentit, destaquem els principals mecanismes endògens de protecció i en descrivim el paper en la promoció de la supervivència neuronal durant la neurodegeneració.

Idioma original	Anglès
Número d’article	370
Pàgines (de-a)	1-21
Nombre de pàgines	21
Revista	Cells
Volum	10
Número	2
DOIs	https://doi.org/10.3390/cells10020370
Estat de la publicació	Publicada - de febr. 2021

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10.3390/cells10020370

https://ddd.uab.cat/record/236697

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title = "Endogenous mechanisms of neuroprotection: To boost or not to boost",

abstract = "Postmitotic cells, like neurons, must live through a lifetime. For this reason, organisms/cells have evolved with self‐repair mechanisms that allow them to have a long life. The discovery workflow of neuroprotectors during the last years has focused on blocking the pathophysiological mechanisms that lead to neuronal loss in neurodegeneration. Unfortunately, only a few strategies from these studies were able to slow down or prevent neurodegeneration. There is compelling evidence demonstrating that endorsing the self‐healing mechanisms that organisms/cells endogenously have, commonly referred to as cellular resilience, can arm neurons and promote their self‐healing. Although enhancing these mechanisms has not yet received sufficient attention, these pathways open up new therapeutic avenues to prevent neuronal death and ameliorate neurodegeneration. Here, we highlight the main endogenous mechanisms of protection and describe their role in promoting neuron survival during neurodegeneration.",

keywords = "Autophagy, Cellular resilience, Endogenous mechanisms, Neuronal survival, Neuroprotection, Unfolded protein response",

author = "Sara Marmolejo‐Mart{\'i}nez‐Artesero and Caty Casas and David Romeo‐Guitart",

note = "Publisher Copyright: {\textcopyright} 2021 by the author. Licensee MDPI, Basel, Switzerland.",

year = "2021",

month = feb,

doi = "10.3390/cells10020370",

language = "English",

volume = "10",

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T2 - To boost or not to boost

AU - Marmolejo‐Martínez‐Artesero, Sara

AU - Casas, Caty

AU - Romeo‐Guitart, David

PY - 2021/2

Y1 - 2021/2

N2 - Postmitotic cells, like neurons, must live through a lifetime. For this reason, organisms/cells have evolved with self‐repair mechanisms that allow them to have a long life. The discovery workflow of neuroprotectors during the last years has focused on blocking the pathophysiological mechanisms that lead to neuronal loss in neurodegeneration. Unfortunately, only a few strategies from these studies were able to slow down or prevent neurodegeneration. There is compelling evidence demonstrating that endorsing the self‐healing mechanisms that organisms/cells endogenously have, commonly referred to as cellular resilience, can arm neurons and promote their self‐healing. Although enhancing these mechanisms has not yet received sufficient attention, these pathways open up new therapeutic avenues to prevent neuronal death and ameliorate neurodegeneration. Here, we highlight the main endogenous mechanisms of protection and describe their role in promoting neuron survival during neurodegeneration.

AB - Postmitotic cells, like neurons, must live through a lifetime. For this reason, organisms/cells have evolved with self‐repair mechanisms that allow them to have a long life. The discovery workflow of neuroprotectors during the last years has focused on blocking the pathophysiological mechanisms that lead to neuronal loss in neurodegeneration. Unfortunately, only a few strategies from these studies were able to slow down or prevent neurodegeneration. There is compelling evidence demonstrating that endorsing the self‐healing mechanisms that organisms/cells endogenously have, commonly referred to as cellular resilience, can arm neurons and promote their self‐healing. Although enhancing these mechanisms has not yet received sufficient attention, these pathways open up new therapeutic avenues to prevent neuronal death and ameliorate neurodegeneration. Here, we highlight the main endogenous mechanisms of protection and describe their role in promoting neuron survival during neurodegeneration.

KW - Autophagy

KW - Cellular resilience

KW - Endogenous mechanisms

KW - Neuronal survival

KW - Neuroprotection

KW - Unfolded protein response

UR - https://www.scopus.com/pages/publications/85101448937

U2 - 10.3390/cells10020370

DO - 10.3390/cells10020370

M3 - Review article

C2 - 33578870

AN - SCOPUS:85101448937

SN - 2073-4409

VL - 10

SP - 1

EP - 21

JO - Cells

JF - Cells

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M1 - 370

ER -

Endogenous mechanisms of neuroprotection: To boost or not to boost

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