Enantioselective synthesis of hydroxy α-amino acids. (-)-erythro- and (-) -threo-γ-hydroxynorvalines

Jesus Ariza; Josep Font; Rosa M. Ortuño

doi:10.1016/S0040-4020(01)89761-1

Enantioselective synthesis of hydroxy α-amino acids. (-)-erythro- and (-) -threo-γ-hydroxynorvalines

Jesus Ariza, Josep Font, Rosa M. Ortuño

Departament de Química

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The amino acids (-)-erythro- and (-)-threo-γ-hydroxynorvaline have been synthesized from D-ribonolactone, 6, as single chiral precursor. Moreover, β-hydrox-αazido- γ-valerolactones 12a and 12b have been also prepared from 6 in two different alternative ways. These compounds afford β,γ-dihydroxy-α -amino acids 18a and 18b with Darabino and D-ribo configuration, respectively. © 1990.

Idioma original	Anglès
Pàgines (de-a)	1931-1942
Revista	Tetrahedron
Volum	46
Número	6
DOIs	https://doi.org/10.1016/S0040-4020(01)89761-1
Estat de la publicació	Publicada - 1 de gen. 1990

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10.1016/S0040-4020(01)89761-1

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title = "Enantioselective synthesis of hydroxy α-amino acids. (-)-erythro- and (-) -threo-γ-hydroxynorvalines",

abstract = "The amino acids (-)-erythro- and (-)-threo-γ-hydroxynorvaline have been synthesized from D-ribonolactone, 6, as single chiral precursor. Moreover, β-hydrox-αazido- γ-valerolactones 12a and 12b have been also prepared from 6 in two different alternative ways. These compounds afford β,γ-dihydroxy-α -amino acids 18a and 18b with Darabino and D-ribo configuration, respectively. {\textcopyright} 1990.",

author = "Jesus Ariza and Josep Font and Ortu{\~n}o, {Rosa M.}",

year = "1990",

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doi = "10.1016/S0040-4020(01)89761-1",

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AU - Ariza, Jesus

AU - Font, Josep

AU - Ortuño, Rosa M.

PY - 1990/1/1

Y1 - 1990/1/1

N2 - The amino acids (-)-erythro- and (-)-threo-γ-hydroxynorvaline have been synthesized from D-ribonolactone, 6, as single chiral precursor. Moreover, β-hydrox-αazido- γ-valerolactones 12a and 12b have been also prepared from 6 in two different alternative ways. These compounds afford β,γ-dihydroxy-α -amino acids 18a and 18b with Darabino and D-ribo configuration, respectively. © 1990.

AB - The amino acids (-)-erythro- and (-)-threo-γ-hydroxynorvaline have been synthesized from D-ribonolactone, 6, as single chiral precursor. Moreover, β-hydrox-αazido- γ-valerolactones 12a and 12b have been also prepared from 6 in two different alternative ways. These compounds afford β,γ-dihydroxy-α -amino acids 18a and 18b with Darabino and D-ribo configuration, respectively. © 1990.

U2 - 10.1016/S0040-4020(01)89761-1

DO - 10.1016/S0040-4020(01)89761-1

M3 - Article

SN - 0040-4020

VL - 46

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JO - Tetrahedron

JF - Tetrahedron

IS - 6

ER -

Enantioselective synthesis of hydroxy α-amino acids. (-)-erythro- and (-) -threo-γ-hydroxynorvalines

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