Enantiodifferentiation through frequency-selective pure-shift 1H nuclear magnetic resonance spectroscopy

Laura Castañar; Míriam Pérez-Trujillo; Pau Nolis; Eva Monteagudo; Albert Virgili; Teodor Parella

doi:10.1002/cphc.201301130

Enantiodifferentiation through frequency-selective pure-shift ¹H nuclear magnetic resonance spectroscopy

Laura Castañar, Míriam Pérez-Trujillo, Pau Nolis, Eva Monteagudo, Albert Virgili, Teodor Parella

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Resum

A frequency-selective 1D 1H nuclear magnetic resonance (NMR) experiment for the fast and sensitive determination of chemical-shift differences between overlapped resonances is proposed. The resulting fully homodecoupled 1H NMR resonances appear as resolved 1D singlets without their typical J(HH) coupling constant multiplet structures. The high signal dispersion that is achieved is then exploited in enantiodiscrimination studies by using chiral solvating agents. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Idioma original	English
Pàgines (de-a)	854-857
Revista	ChemPhysChem
Volum	15
Número	5
DOIs	https://doi.org/10.1002/cphc.201301130
Estat de la publicació	Publicada - 4 d’abr. 2014

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10.1002/cphc.201301130

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@article{885c3b8c1d214ffdb484eae9bb286797,

title = "Enantiodifferentiation through frequency-selective pure-shift 1H nuclear magnetic resonance spectroscopy",

abstract = "A frequency-selective 1D 1H nuclear magnetic resonance (NMR) experiment for the fast and sensitive determination of chemical-shift differences between overlapped resonances is proposed. The resulting fully homodecoupled 1H NMR resonances appear as resolved 1D singlets without their typical J(HH) coupling constant multiplet structures. The high signal dispersion that is achieved is then exploited in enantiodiscrimination studies by using chiral solvating agents. {\textcopyright} 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.",

keywords = "chemical shift, enantioselectivity, homodecoupling, nmr spectroscopy, single pulsed-field-gradient echo",

author = "Laura Casta{\~n}ar and M{\'i}riam P{\'e}rez-Trujillo and Pau Nolis and Eva Monteagudo and Albert Virgili and Teodor Parella",

year = "2014",

month = apr,

day = "4",

doi = "10.1002/cphc.201301130",

language = "English",

volume = "15",

pages = "854--857",

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TY - JOUR

T1 - Enantiodifferentiation through frequency-selective pure-shift 1H nuclear magnetic resonance spectroscopy

AU - Castañar, Laura

AU - Pérez-Trujillo, Míriam

AU - Nolis, Pau

AU - Monteagudo, Eva

AU - Virgili, Albert

AU - Parella, Teodor

PY - 2014/4/4

Y1 - 2014/4/4

N2 - A frequency-selective 1D 1H nuclear magnetic resonance (NMR) experiment for the fast and sensitive determination of chemical-shift differences between overlapped resonances is proposed. The resulting fully homodecoupled 1H NMR resonances appear as resolved 1D singlets without their typical J(HH) coupling constant multiplet structures. The high signal dispersion that is achieved is then exploited in enantiodiscrimination studies by using chiral solvating agents. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

AB - A frequency-selective 1D 1H nuclear magnetic resonance (NMR) experiment for the fast and sensitive determination of chemical-shift differences between overlapped resonances is proposed. The resulting fully homodecoupled 1H NMR resonances appear as resolved 1D singlets without their typical J(HH) coupling constant multiplet structures. The high signal dispersion that is achieved is then exploited in enantiodiscrimination studies by using chiral solvating agents. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

KW - chemical shift

KW - enantioselectivity

KW - homodecoupling

KW - nmr spectroscopy

KW - single pulsed-field-gradient echo

U2 - 10.1002/cphc.201301130

DO - 10.1002/cphc.201301130

M3 - Article

SN - 1439-4235

VL - 15

SP - 854

EP - 857

JO - ChemPhysChem

JF - ChemPhysChem

IS - 5

ER -

Enantiodifferentiation through frequency-selective pure-shift 1H nuclear magnetic resonance spectroscopy

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Enantiodifferentiation through frequency-selective pure-shift ¹H nuclear magnetic resonance spectroscopy