TY - JOUR
T1 - Electrochemical synthesis of nitroaromatic ketones
AU - Gallardo, Iluminada
AU - Guirado, Gonzalo
AU - Marquet, Jordi
PY - 2002/1/1
Y1 - 2002/1/1
N2 - Nitroaromatic ketones are readily prepared by nucleophilic aromatic substitution of hydrogen in nitroarenes by electrochemical oxidation. Carbanions of various ketones were added to selected nitroarenes in DMF/ketone mixtures leading to formation of the o11 complexes. The reaction was promoted using potassium feri-butoxide as a base. Useful yields were achieved (80-100%) in the C-arylation of ketones. In most cases, the process proceeded with high selectivity. This new method represents an environmentally favourable route for obtaining nitroaromatic ketones. © WILEY-VCH Verlag GmbH, 2002.
AB - Nitroaromatic ketones are readily prepared by nucleophilic aromatic substitution of hydrogen in nitroarenes by electrochemical oxidation. Carbanions of various ketones were added to selected nitroarenes in DMF/ketone mixtures leading to formation of the o11 complexes. The reaction was promoted using potassium feri-butoxide as a base. Useful yields were achieved (80-100%) in the C-arylation of ketones. In most cases, the process proceeded with high selectivity. This new method represents an environmentally favourable route for obtaining nitroaromatic ketones. © WILEY-VCH Verlag GmbH, 2002.
KW - Electrochemistry
KW - Ketones
KW - Nucleophilic substitution
KW - Oxidations
UR - https://www.scopus.com/pages/publications/0036153901
U2 - 10.1002/1099-0690(20021)2002:2<261::AID-EJOC261>3.0.CO;2-6
DO - 10.1002/1099-0690(20021)2002:2<261::AID-EJOC261>3.0.CO;2-6
M3 - Article
SN - 1434-193X
VL - 2
SP - 261
EP - 267
JO - European Journal of Organic Chemistry
JF - European Journal of Organic Chemistry
IS - 2
ER -