Electrochemical synthesis of nitroaromatic ketones

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Resum

Nitroaromatic ketones are readily prepared by nucleophilic aromatic substitution of hydrogen in nitroarenes by electrochemical oxidation. Carbanions of various ketones were added to selected nitroarenes in DMF/ketone mixtures leading to formation of the o11 complexes. The reaction was promoted using potassium feri-butoxide as a base. Useful yields were achieved (80-100%) in the C-arylation of ketones. In most cases, the process proceeded with high selectivity. This new method represents an environmentally favourable route for obtaining nitroaromatic ketones. © WILEY-VCH Verlag GmbH, 2002.
Idioma originalEnglish
Pàgines (de-a)261-267
RevistaEuropean Journal of Organic Chemistry
Volum2
Número2
DOIs
Estat de la publicacióPublicada - 1 de gen. 2002

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