TY - JOUR
T1 - Electrical Conductivity Measurement in Human Liver Tissue
T2 - Assessment on Normal vs. Tumor Tissue and under In Vivo vs. Ex Vivo Conditions
AU - Sarreshtehdari, Amirhossein
AU - García-Sánchez, Tomás
AU - Sánchez-Velázquez, Patricia
AU - Ielpo, Benedetto
AU - Berjano, Enrique
AU - Villamonte, María
AU - Moll, Xavier
AU - Burdio, Fernando
N1 - Publisher Copyright:
© 2024 by the authors.
PY - 2024/8/8
Y1 - 2024/8/8
N2 - Background: This study evaluated electrical conductivity in human liver tissue in the 3–1000 kHz frequency range to compare normal versus tumor tissues under in vivo versus ex vivo conditions. Methods: Previous informed consent was obtained from twenty patients undergoing liver resection in whom liver electrical conductivity was measured during surgery and after resection. Result: We found higher electrical conductivity values in tumor tissues than in normal tissue in both in vivo (0.41 ± 0.10 vs. 0.13 ± 0.06 S/m) and ex vivo (0.27 ± 0.09 vs. 0.12 ± 0.07 S/m) conditions (at 3 kHz). The electric properties also showed a promising potential for distinguishing between different tissue types including metastasis, cholangiocarcinoma (CCA), hepatocellular carcinoma (HCC), hepatic cirrhosis, and normal liver (both in vivo and ex vivo). At 3 kHz, in vivo electrical conductivity for cholangiocarcinoma, HCC, and metastasis were 0.35, 0.42 ± 0.13, and 0.41 ± 0.08 S/m, respectively, which differed significantly from each other (p < 0.05). Conclusions: These findings could potentially improve liver disease diagnostics through electrical conductivity measurements and treatment techniques involving electric fields. Future research should focus on expanding the sample size to refine the categorization and comparison processes across diverse human liver tissue types.
AB - Background: This study evaluated electrical conductivity in human liver tissue in the 3–1000 kHz frequency range to compare normal versus tumor tissues under in vivo versus ex vivo conditions. Methods: Previous informed consent was obtained from twenty patients undergoing liver resection in whom liver electrical conductivity was measured during surgery and after resection. Result: We found higher electrical conductivity values in tumor tissues than in normal tissue in both in vivo (0.41 ± 0.10 vs. 0.13 ± 0.06 S/m) and ex vivo (0.27 ± 0.09 vs. 0.12 ± 0.07 S/m) conditions (at 3 kHz). The electric properties also showed a promising potential for distinguishing between different tissue types including metastasis, cholangiocarcinoma (CCA), hepatocellular carcinoma (HCC), hepatic cirrhosis, and normal liver (both in vivo and ex vivo). At 3 kHz, in vivo electrical conductivity for cholangiocarcinoma, HCC, and metastasis were 0.35, 0.42 ± 0.13, and 0.41 ± 0.08 S/m, respectively, which differed significantly from each other (p < 0.05). Conclusions: These findings could potentially improve liver disease diagnostics through electrical conductivity measurements and treatment techniques involving electric fields. Future research should focus on expanding the sample size to refine the categorization and comparison processes across diverse human liver tissue types.
KW - electrical conductivity
KW - ex vivo
KW - human liver
KW - in vivo
KW - tumor
UR - http://www.scopus.com/inward/record.url?scp=85202339718&partnerID=8YFLogxK
UR - https://www.mendeley.com/catalogue/8ab3aead-a767-3836-b6c4-b92c492c4eec/
U2 - 10.3390/bios14080382
DO - 10.3390/bios14080382
M3 - Article
C2 - 39194611
AN - SCOPUS:85202339718
SN - 2079-6374
VL - 14
JO - Biosensors
JF - Biosensors
IS - 8
M1 - 382
ER -