TY - JOUR
T1 - Elderly patients with hormone receptor-positive HER2-negative metastatic breast cancer treated with CDK4/6 inhibitors in a multicentre cohort
AU - Pla, Helena
AU - Felip, Eudald
AU - Obadia, Verónica
AU - Pernas, Sonia
AU - Viñas, Gemma
AU - Margelí, Mireia
AU - Fort-Culillas, Roser
AU - Del Barco, Sonia
AU - Sabaté, Nuria
AU - Fort, Eduard
AU - Lezcano, Clara
AU - Cirauqui, Beatriz
AU - Quiroga, Vanesa
AU - Stradella, Agostina
AU - Gil Gil, Miguel
AU - Esteve, Anna
AU - Recalde, Sabela
N1 - Publisher Copyright:
© The Author(s) 2024.
PY - 2024/3/22
Y1 - 2024/3/22
N2 - Introduction Cyclin-dependent kinases 4/6 inhibitors (CDK 4/6i) combined with endocrine therapy have become the gold standard in hormone receptor-positive (HR +) HER2-negative (HER2-) metastatic breast cancer (MBC). However, there is a significant lack of data regarding the efficacy and safety of these treatments in elderly patients. We present the results of a real-world data (RWD) cohort stratified by age at treatment initiation (>= 70 years compared to patients < 70 years). Methods Clinico-pathological data of HR + HER2- MBC patients who were candidates for CDK4/6i therapy between January 2017 and December 2020 at the Institut Catala d'Oncologia (Spain) were retrospectively collected. The primary goal was to assess Progression-Free Survival (PFS), Overall Survival (OS), and safety outcomes within this patient population. Results A total of 274 patients with MBC who received CDK4/6i treatment were included in the study. Among them, 84 patients (30.8%) were aged >= 70 years, with a mean age of 75, while 190 patients (69.2%) were under the age of 70, with a mean age of 55.7 years. The most frequently observed grade 3-4 toxicity was neutropenia, with similar rates in both the < 70 group (43.9%) and the >= 70 group (47.9%) (p = 0.728). The median Progression-Free Survival (mPFS) for the first-line CDK4/6i treatment was 22 months (95% CI, 15.4-39.8) in the < 70 group and 20.8 months (95% CI 11.2-NR) in the >= 70 group (p = 0.67). Similarly, the median PFS for the second-line CDK4/6i treatment was 10.4 months (95% CI, 7.4-15.1) and 7.1 months (95% CI 4.4-21.3) (p = 0.79), respectively. Median overall survival (mOS) was not reached either for the first- and second-line treatment. Conclusions Our RWD suggests that elderly patients, when compared to those under 70, experience similar survival outcomes and exhibit comparable tolerance for CDK4/6i therapy.
AB - Introduction Cyclin-dependent kinases 4/6 inhibitors (CDK 4/6i) combined with endocrine therapy have become the gold standard in hormone receptor-positive (HR +) HER2-negative (HER2-) metastatic breast cancer (MBC). However, there is a significant lack of data regarding the efficacy and safety of these treatments in elderly patients. We present the results of a real-world data (RWD) cohort stratified by age at treatment initiation (>= 70 years compared to patients < 70 years). Methods Clinico-pathological data of HR + HER2- MBC patients who were candidates for CDK4/6i therapy between January 2017 and December 2020 at the Institut Catala d'Oncologia (Spain) were retrospectively collected. The primary goal was to assess Progression-Free Survival (PFS), Overall Survival (OS), and safety outcomes within this patient population. Results A total of 274 patients with MBC who received CDK4/6i treatment were included in the study. Among them, 84 patients (30.8%) were aged >= 70 years, with a mean age of 75, while 190 patients (69.2%) were under the age of 70, with a mean age of 55.7 years. The most frequently observed grade 3-4 toxicity was neutropenia, with similar rates in both the < 70 group (43.9%) and the >= 70 group (47.9%) (p = 0.728). The median Progression-Free Survival (mPFS) for the first-line CDK4/6i treatment was 22 months (95% CI, 15.4-39.8) in the < 70 group and 20.8 months (95% CI 11.2-NR) in the >= 70 group (p = 0.67). Similarly, the median PFS for the second-line CDK4/6i treatment was 10.4 months (95% CI, 7.4-15.1) and 7.1 months (95% CI 4.4-21.3) (p = 0.79), respectively. Median overall survival (mOS) was not reached either for the first- and second-line treatment. Conclusions Our RWD suggests that elderly patients, when compared to those under 70, experience similar survival outcomes and exhibit comparable tolerance for CDK4/6i therapy.
KW - CDK4/6 inhibitors
KW - Elderly population
KW - Metastatic breast cancer
KW - Real world
KW - Toxicity
UR - http://www.scopus.com/inward/record.url?scp=85188284599&partnerID=8YFLogxK
UR - https://www.mendeley.com/catalogue/1cf2c3bc-e5b5-3c4a-941f-46d298157a11/
UR - https://portalrecerca.uab.cat/en/publications/4cc89d3c-1dec-4263-a916-34a475985913
U2 - 10.1007/s12094-024-03399-3
DO - 10.1007/s12094-024-03399-3
M3 - Article
C2 - 38519708
AN - SCOPUS:85188284599
SN - 1699-048X
VL - 26
SP - 1748
EP - 1758
JO - Clinical and Translational Oncology
JF - Clinical and Translational Oncology
IS - 7
ER -