Resum
Reducing the heart rate is one of the basic aims of treatment for chronic stable angina; it has an influence on both symptoms and prognosis. Beta-blockers, and to a lesser extent non-dihydropyridine calcium channel blockers, derive part of their antianginal effect from this mechanism. Ivabradine, a selective inhibitor of the If current in sinus node cells, markedly prolongs the spontaneous diastolic depolarization time and, thereby, significantly reduces the heart rate, both at rest and during exercise. Moreover, the drug has no other hemodynamic effects, unlike beta-blockers and calcium channel blockers, which have a similar effect on the heart rate. Studies in healthy volunteers and patients with chronic, stable, lifestyle-limiting exercise-induced angina have demonstrated ivabradine's effectiveness at different doses compared with placebo. Moreover, compared with beta-blockers, calcium channel blockers and their combination, the drug has also been shown to result in a clear improvement in anginal symptoms and in increased exercise tolerance.
Títol traduït de la contribució | The antianginal effects of ivabradine. Its mechanism of action differentiates it from other antianginal drugs |
---|---|
Idioma original | Espanyol |
Pàgines (de-a) | 46D-52D |
Nombre de pàgines | 7 |
Revista | Revista Espanola de Cardiologia Suplementos |
Volum | 7 |
Número | D |
Estat de la publicació | Publicada - de juny 2007 |
Keywords
- Heart rate
- Sinus node
- Stable angina