Eficacia antianginosa de la ivabradina. Mecanismos de acción diferenciales con otros fármacos antianginosos

Jordi Bruguera-Cortada*, Cosme García-García

*Autor corresponent d’aquest treball

Producció científica: Contribució a revistaArticle de revisióRecercaAvaluat per experts

Resum

Reducing the heart rate is one of the basic aims of treatment for chronic stable angina; it has an influence on both symptoms and prognosis. Beta-blockers, and to a lesser extent non-dihydropyridine calcium channel blockers, derive part of their antianginal effect from this mechanism. Ivabradine, a selective inhibitor of the If current in sinus node cells, markedly prolongs the spontaneous diastolic depolarization time and, thereby, significantly reduces the heart rate, both at rest and during exercise. Moreover, the drug has no other hemodynamic effects, unlike beta-blockers and calcium channel blockers, which have a similar effect on the heart rate. Studies in healthy volunteers and patients with chronic, stable, lifestyle-limiting exercise-induced angina have demonstrated ivabradine's effectiveness at different doses compared with placebo. Moreover, compared with beta-blockers, calcium channel blockers and their combination, the drug has also been shown to result in a clear improvement in anginal symptoms and in increased exercise tolerance.
Títol traduït de la contribucióThe antianginal effects of ivabradine. Its mechanism of action differentiates it from other antianginal drugs
Idioma originalEspanyol
Pàgines (de-a)46D-52D
Nombre de pàgines7
RevistaRevista Espanola de Cardiologia Suplementos
Volum7
NúmeroD
Estat de la publicacióPublicada - de juny 2007

Keywords

  • Heart rate
  • Sinus node
  • Stable angina

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