Resum
Objective: Dietary lipids influence breast cancer. We
investigated the clinical and histopathological (HP) effects,
and on p21HaRas expression, of two high-fat diets on
DMBA-induced mammary carcinogenesis.
Method: Three groups of 20 Sprague–Dawley rats each
had: low-fat (LFCO), high-fat corn oil (HFCOP), and high
fat extravirgin olive oil (HFOOP), given 5 mg DMBA at
53 days. Analysis of latency time (LT), tumour incidence
(TI) and total and rat tumour yield (TTY, RTY), of seven
HP parameters and of rat mammary carcinomas grading
method. Immunohistochemistry (antip21HaRas) evaluated
with NOESISVISILOG5.1.
Results: HighCO diet reduced LT (77.3 ± 32.1) and
increased TI (90%), TTY (95) and RTY (3.5). HFOOP
displayed similar LT (102.3±47.4), higher TI (80%) and
lower TTY (69) and RTY (2.5) than LFCO (102.5±
42.3;70%;72 and 3). LFCO adenocarcinomas exhibited
lower histological grade (72.5% grade1) and profile than
HFCOP (59.3% grade1) and were similar to HFOOP
(64.2% grade1). No differences in p21Ha-Ras expression
among dietary groups but a significant p21HaRas decreasing expressions as grade increased were noted (grade 1,
56.69% positive; grade 3, 43.1%), except in HFOOP.
Conclusion: Dietary lipids influence the clinical and
morphological characteristics of experimental mammary
carcinogenesis, without altering p21HaRas expression,
which could be affected by the malignancy of tumours,
probably through a posttranslational event.
investigated the clinical and histopathological (HP) effects,
and on p21HaRas expression, of two high-fat diets on
DMBA-induced mammary carcinogenesis.
Method: Three groups of 20 Sprague–Dawley rats each
had: low-fat (LFCO), high-fat corn oil (HFCOP), and high
fat extravirgin olive oil (HFOOP), given 5 mg DMBA at
53 days. Analysis of latency time (LT), tumour incidence
(TI) and total and rat tumour yield (TTY, RTY), of seven
HP parameters and of rat mammary carcinomas grading
method. Immunohistochemistry (antip21HaRas) evaluated
with NOESISVISILOG5.1.
Results: HighCO diet reduced LT (77.3 ± 32.1) and
increased TI (90%), TTY (95) and RTY (3.5). HFOOP
displayed similar LT (102.3±47.4), higher TI (80%) and
lower TTY (69) and RTY (2.5) than LFCO (102.5±
42.3;70%;72 and 3). LFCO adenocarcinomas exhibited
lower histological grade (72.5% grade1) and profile than
HFCOP (59.3% grade1) and were similar to HFOOP
(64.2% grade1). No differences in p21Ha-Ras expression
among dietary groups but a significant p21HaRas decreasing expressions as grade increased were noted (grade 1,
56.69% positive; grade 3, 43.1%), except in HFOOP.
Conclusion: Dietary lipids influence the clinical and
morphological characteristics of experimental mammary
carcinogenesis, without altering p21HaRas expression,
which could be affected by the malignancy of tumours,
probably through a posttranslational event.
| Idioma original | Anglès |
|---|---|
| Pàgines (de-a) | S67-S67 |
| Nombre de pàgines | 1 |
| Revista | Virchows Archiv |
| Volum | 459 |
| Número | Supl. 1 |
| DOIs | |
| Estat de la publicació | Publicada - d’ag. 2011 |
SDG de les Nacions Unides
Aquest resultat contribueix als següents objectius de desenvolupament sostenible.
