Effects of dizocilpine on autotomy behavior after nerve section in mice

Josep E. Baños, Enrique Verdú, Miquel Butí, Xavier Navarro

    Producció científica: Contribució a una revistaArticleRecercaAvaluat per experts

    8 Cites (Scopus)

    Resum

    The effects of acute administration of dizocilpine (MK-801) at different perioperative times on autotomy behavior after sciatic and saphenous nerve transection were studied in the mouse. Control mice developed a severe self-mutilating behavior starting 1-3 days postoperation and reaching a maximum by 11 days. Mice injected with a single dose of dizocilpine (0.4 mg/kg i.p.) before operation, the 1st or 3rd postoperative day autotomized significantly less than controls. An 1-wk treatment with the same dose once a day did not show further benefit. A single administration of dizocilpine the 5th day after surgery slightly halted further progression of autotomy. Dizocilpine did not have any deleterious effect on normal peripheral nerve function. These results suggest that NMDA receptor blockade prevents development of hyperalgesia and neuropathic pain after peripheral nerve injuries but only when it is administered before or during the first 3 days after injury. © 1994.
    Idioma originalEnglish
    Pàgines (de-a)107-110
    RevistaBrain Research
    Volum636
    DOIs
    Estat de la publicacióPublicada - 4 de febr. 1994

    Fingerprint

    Navegar pels temes de recerca de 'Effects of dizocilpine on autotomy behavior after nerve section in mice'. Junts formen un fingerprint únic.

    Com citar-ho