Effect of heparin on lecithin:Cholesterol acyltransferase and lipids in cholestasis

J. Rubiés-Prat; M. R. Ras; J. C. Frisón; C. Miquel; S. Masdeu; R. Bacardi

doi:10.1159/000197938

Effect of heparin on lecithin:Cholesterol acyltransferase and lipids in cholestasis

J. Rubiés-Prat, M. R. Ras, J. C. Frisón, C. Miquel, S. Masdeu, R. Bacardi

Departament de Medicina

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The effect of heparin on the proportion of cholesterol esters, lecithin/ lysolecithin ratio, and lecithin:cholesterol acyltransferase (LCAT) activity was studied in twelve patients with cholestasis. A good correlation was observed between a decreased LCAT activity and the proportion of cholesterol esters, and no consistent variation was noted after heparin. The lecithin/lysolecithin ratio was increased in 7 patients and became normal after heparin in 6 cases. The clearance of lipoprotein-X after heparin seems to be not related to LCAT activity. These results demonstrate that heparin does not modify the LCAT activity, and suggest that heparin induces an increase of phospholipase activity in some patients with cholestasis. © 1976 S. Karger AG, Basel.

Idioma original	Anglès
Pàgines (de-a)	250-255
Revista	Digestion
Volum	14
Número	3
DOIs	https://doi.org/10.1159/000197938
Estat de la publicació	Publicada - 1 de gen. 1976

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10.1159/000197938

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@article{85c579e33b6044e2bd96f0926605b783,

title = "Effect of heparin on lecithin:Cholesterol acyltransferase and lipids in cholestasis",

abstract = "The effect of heparin on the proportion of cholesterol esters, lecithin/ lysolecithin ratio, and lecithin:cholesterol acyltransferase (LCAT) activity was studied in twelve patients with cholestasis. A good correlation was observed between a decreased LCAT activity and the proportion of cholesterol esters, and no consistent variation was noted after heparin. The lecithin/lysolecithin ratio was increased in 7 patients and became normal after heparin in 6 cases. The clearance of lipoprotein-X after heparin seems to be not related to LCAT activity. These results demonstrate that heparin does not modify the LCAT activity, and suggest that heparin induces an increase of phospholipase activity in some patients with cholestasis. {\textcopyright} 1976 S. Karger AG, Basel.",

keywords = "Cholestasis, Cholesterol, Heparin, Lecithin: cholesterol acyltransferase, Lipids, Lipoprotein-X, Liver diseases, Phospholipase",

author = "J. Rubi{\'e}s-Prat and Ras, {M. R.} and Fris{\'o}n, {J. C.} and C. Miquel and S. Masdeu and R. Bacardi",

year = "1976",

month = jan,

day = "1",

doi = "10.1159/000197938",

language = "English",

volume = "14",

pages = "250--255",

journal = "Digestion",

issn = "0012-2823",

number = "3",

}

TY - JOUR

T1 - Effect of heparin on lecithin:Cholesterol acyltransferase and lipids in cholestasis

AU - Rubiés-Prat, J.

AU - Ras, M. R.

AU - Frisón, J. C.

AU - Miquel, C.

AU - Masdeu, S.

AU - Bacardi, R.

PY - 1976/1/1

Y1 - 1976/1/1

N2 - The effect of heparin on the proportion of cholesterol esters, lecithin/ lysolecithin ratio, and lecithin:cholesterol acyltransferase (LCAT) activity was studied in twelve patients with cholestasis. A good correlation was observed between a decreased LCAT activity and the proportion of cholesterol esters, and no consistent variation was noted after heparin. The lecithin/lysolecithin ratio was increased in 7 patients and became normal after heparin in 6 cases. The clearance of lipoprotein-X after heparin seems to be not related to LCAT activity. These results demonstrate that heparin does not modify the LCAT activity, and suggest that heparin induces an increase of phospholipase activity in some patients with cholestasis. © 1976 S. Karger AG, Basel.

AB - The effect of heparin on the proportion of cholesterol esters, lecithin/ lysolecithin ratio, and lecithin:cholesterol acyltransferase (LCAT) activity was studied in twelve patients with cholestasis. A good correlation was observed between a decreased LCAT activity and the proportion of cholesterol esters, and no consistent variation was noted after heparin. The lecithin/lysolecithin ratio was increased in 7 patients and became normal after heparin in 6 cases. The clearance of lipoprotein-X after heparin seems to be not related to LCAT activity. These results demonstrate that heparin does not modify the LCAT activity, and suggest that heparin induces an increase of phospholipase activity in some patients with cholestasis. © 1976 S. Karger AG, Basel.

KW - Cholestasis

KW - Cholesterol

KW - Heparin

KW - Lecithin: cholesterol acyltransferase

KW - Lipids

KW - Lipoprotein-X

KW - Liver diseases

KW - Phospholipase

U2 - 10.1159/000197938

DO - 10.1159/000197938

M3 - Article

SN - 0012-2823

VL - 14

SP - 250

EP - 255

JO - Digestion

JF - Digestion

IS - 3

ER -

Effect of heparin on lecithin:Cholesterol acyltransferase and lipids in cholestasis

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