TY - JOUR
T1 - Effect of atorvastatin on lipoprotein (a) and interleukin-10: A randomized placebo-controlled trial
AU - Hernández, C.
AU - Francisco, G.
AU - Ciudin, A.
AU - Chacón, P.
AU - Montoro, B.
AU - Llaverias, G.
AU - Blanco-Vaca, F.
AU - Simó, R.
PY - 2011/4/1
Y1 - 2011/4/1
N2 - Aim: This study aimed to determine the effect of atorvastatin therapy on plasma lipoprotein (a) [Lp(a)] and biomarkers of inflammation in hypercholesterolaemic patients free of cardiovascular disease. Methods: In this three-month randomized double-blind placebo-controlled trial, 63 hypercholesterolaemic patients were randomly treated with either placebo or atorvastatin (10 or 40. mg/day) for 12 weeks. Lp(a) and biomarkers of inflammation (C-reactive protein [CRP], interleukin [IL]-6 and -10, and tumour necrosis factor-alpha receptors [TNF-Rs]) were measured at study entry, and at four and 12 weeks of follow-up. Results: At the end of the study, patients allocated to atorvastatin (10 or 40. mg/day) presented with significantly lower Lp(a) levels than those taking placebo (10 [1-41]. mg/dL versus 6 [1-38]. mg/dL [. P = 0.02] and 21 [1-138]. mg/dL versus 15 [1-103]. mg/dL [. P = 0.04], respectively]. In multivariate analyses, the relative changes in Lp(a) were independently related to baseline Lp(a) levels and CRP changes. No significant changes in CRP, IL-6 and TNF-Rs were observed. In contrast, IL-10 (pg/mL) increased significantly in patients taking atorvastatin (2.14 [0.49-43]. pg/mL versus 4.54 [0.51-37.5]. pg/mL; P = 0.01), and was even more increased with the 40-mg dose than with 10. mg. Conclusion: Our results suggest that 12-week atorvastatin is effective in reducing Lp(a) in dyslipidaemic patients free of CVD. Furthermore, this is also the first evidence that the drug increases IL-10 in a dose-dependent manner. © 2010 Elsevier Masson SAS.
AB - Aim: This study aimed to determine the effect of atorvastatin therapy on plasma lipoprotein (a) [Lp(a)] and biomarkers of inflammation in hypercholesterolaemic patients free of cardiovascular disease. Methods: In this three-month randomized double-blind placebo-controlled trial, 63 hypercholesterolaemic patients were randomly treated with either placebo or atorvastatin (10 or 40. mg/day) for 12 weeks. Lp(a) and biomarkers of inflammation (C-reactive protein [CRP], interleukin [IL]-6 and -10, and tumour necrosis factor-alpha receptors [TNF-Rs]) were measured at study entry, and at four and 12 weeks of follow-up. Results: At the end of the study, patients allocated to atorvastatin (10 or 40. mg/day) presented with significantly lower Lp(a) levels than those taking placebo (10 [1-41]. mg/dL versus 6 [1-38]. mg/dL [. P = 0.02] and 21 [1-138]. mg/dL versus 15 [1-103]. mg/dL [. P = 0.04], respectively]. In multivariate analyses, the relative changes in Lp(a) were independently related to baseline Lp(a) levels and CRP changes. No significant changes in CRP, IL-6 and TNF-Rs were observed. In contrast, IL-10 (pg/mL) increased significantly in patients taking atorvastatin (2.14 [0.49-43]. pg/mL versus 4.54 [0.51-37.5]. pg/mL; P = 0.01), and was even more increased with the 40-mg dose than with 10. mg. Conclusion: Our results suggest that 12-week atorvastatin is effective in reducing Lp(a) in dyslipidaemic patients free of CVD. Furthermore, this is also the first evidence that the drug increases IL-10 in a dose-dependent manner. © 2010 Elsevier Masson SAS.
KW - Atorvastatin
KW - Hypercholesterolaemia
KW - Interleukin-10
KW - Lipoprotein (a)
KW - Randomized study
KW - TNF-α receptor
KW - Vascular inflammation
U2 - 10.1016/j.diabet.2010.08.006
DO - 10.1016/j.diabet.2010.08.006
M3 - Article
SN - 1262-3636
VL - 37
SP - 124
EP - 130
JO - Diabetes and Metabolism
JF - Diabetes and Metabolism
IS - 2
ER -