TY - JOUR
T1 - Drosophila melanogaster as a model to study innate immune memory
AU - Arch, Marta
AU - Vidal, Maria
AU - Koiffman, Romina
AU - Melkie, Solomon Tibebu
AU - Cardona, Pere Joan
N1 - Funding Information:
This research was funded by “La Caixa” Foundation (ID 100010434), under agreement LCF/PR/GN16/10290002, Spanish Government-FEDER Funds through PI17/01511 grant, and the “CIBER Enfermedades Respiratorias” Network (CIBERES). RK, registered in the EMJMD LIVE (Erasmus + Mundus Joint Master Degree Leading International Vaccinology Education), co-funded by the EACEA (Education, Audiovisual and Culture Executive Agency, award 2018-1484) of the European commission, receives a scholarship from the EACEA.
Publisher Copyright:
Copyright © 2022 Arch, Vidal, Koiffman, Melkie and Cardona.
PY - 2022/10/20
Y1 - 2022/10/20
N2 - Over the last decades, research regarding innate immune responses has gained increasing importance. A growing body of evidence supports the notion that the innate arm of the immune system could show memory traits. Such traits are thought to be conserved throughout evolution and provide a survival advantage. Several models are available to study these mechanisms. Among them, we find the fruit fly, Drosophila melanogaster. This non-mammalian model has been widely used for innate immune research since it naturally lacks an adaptive response. Here, we aim to review the latest advances in the study of the memory mechanisms of the innate immune response using this animal model.
AB - Over the last decades, research regarding innate immune responses has gained increasing importance. A growing body of evidence supports the notion that the innate arm of the immune system could show memory traits. Such traits are thought to be conserved throughout evolution and provide a survival advantage. Several models are available to study these mechanisms. Among them, we find the fruit fly, Drosophila melanogaster. This non-mammalian model has been widely used for innate immune research since it naturally lacks an adaptive response. Here, we aim to review the latest advances in the study of the memory mechanisms of the innate immune response using this animal model.
KW - Drosophila melanogaster
KW - infection
KW - innate immune memory
KW - resistance
KW - tolerance
KW - trained immunity
UR - https://www.scopus.com/pages/publications/85141172334
U2 - 10.3389/fmicb.2022.991678
DO - 10.3389/fmicb.2022.991678
M3 - Review article
C2 - 36338030
AN - SCOPUS:85141172334
SN - 1664-302X
VL - 13
JO - Frontiers in Microbiology
JF - Frontiers in Microbiology
M1 - 991678
ER -