Does human papillomavirus infection imply a different prognosis in vulvar squamous cell carcinoma?

Immaculada Alonso, Victoria Fusté, Marta Del Pino, Paola Castillo, Aureli Torné, Pere Fusté, Jose Rios, Jaume Pahisa, Juan Balasch, Jaume Ordi*

*Autor corresponent d’aquest treball

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Resum

Background: Two independent pathways in the development of vulvar squamous cell carcinoma (VSCC) have been described, one related to and the other independent of high-risk human papillomavirus (HR-HPV). The aim of our study was to evaluate whether the HPV status has a prognostic significance or can predict response to radiotherapy. Methods: All VSCC diagnosed from 1995 to 2009 were retrospectively evaluated (n = 98). HPV infection was detected by amplification of HPV DNA by PCR using SPF-10 primers and typed by the INNO-LIPA HPV research assay. p16INK4a expression was determined by immunohistochemistry. Disease-free and overall survival (DFS and OS) were estimated by Kaplan-Meier analysis with the log-rank test and a multivariate Cox proportional hazard's model. Results: HR-HPV DNA was detected in 19.4% of patients. HPV16 was the most prevalent genotype (73.7% of cases). p16INK4a stained 100% HPV-positive and 1.3% HPV-negative tumors (p <.001). No differences were found between HPV-positive and -negative tumors in terms of either DFS (39.8% vs. 49.8% at 5 years; p =.831), or OS (67.2% vs. 71.4% at 5 years; p =.791). No differences in survival were observed between HPV-positive and -negative patients requiring radiotherapy (hazard ratio [HR] 1.04, 95% confidence interval [CI].45 to 2.41). FIGO stages III-IV (p =.002), lymph node metastasis (p =.030), size ≥ 20 mm (p =.023), invasion depth (p =.020) and ulceration (p =.032) were associated with increased mortality but in multivariated only lymph node metastasis retained the association (HR 13.28, 95% CI 1.19 to 148.61). Conclusions: HPV-positive and -negative VSCCs have a similar prognosis. Radiotherapy does not increase survival in HPV-positive women. © 2011 Elsevier Inc.
Idioma originalEnglish
Pàgines (de-a)509-514
Nombre de pàgines6
RevistaGynecologic Oncology
Volum122
Número3
DOIs
Estat de la publicacióPublicada - de set. 2011

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