TY - JOUR
T1 - Do moonlighting proteins belong to the intrinsically disordered protein class?
AU - Hernández, Sergio
AU - Amela, Isaac
AU - Cedano, Juan
AU - Piñol, Jaume
AU - Perez-Pons, Josep Antoni
AU - Mozo-Villarias, Angel
AU - Querol, Enrique
PY - 2012/12/12
Y1 - 2012/12/12
N2 - Moonlighting is the capability of some proteins to execute two or more biological functions. According to some authors, there is a relationship between protein conformational fluctuations and promiscuous functions of proteins. This promiscuity would be due to the conformational properties of the structurally disordered regions. To check if moonlighting proteins belong to the Intrinsically Disordered Protein (IDP) class, we have predicted IDP/IDR (Intrinsically Disordered Regions) for a number of moonlighting proteins. Our results suggest that most moonlighting proteins do not belong to the IDP class. © 2012 Hernández S, et al.
AB - Moonlighting is the capability of some proteins to execute two or more biological functions. According to some authors, there is a relationship between protein conformational fluctuations and promiscuous functions of proteins. This promiscuity would be due to the conformational properties of the structurally disordered regions. To check if moonlighting proteins belong to the Intrinsically Disordered Protein (IDP) class, we have predicted IDP/IDR (Intrinsically Disordered Regions) for a number of moonlighting proteins. Our results suggest that most moonlighting proteins do not belong to the IDP class. © 2012 Hernández S, et al.
KW - Intrinsically disordered proteins
KW - Intrinsically disordered regions
KW - Moonlighting proteins
KW - Multitasking proteins
U2 - 10.4172/jpb.1000247
DO - 10.4172/jpb.1000247
M3 - Article
SN - 0974-276X
VL - 5
SP - 262
EP - 264
JO - Journal of Proteomics and Bioinformatics
JF - Journal of Proteomics and Bioinformatics
IS - 11
ER -