DNA hypermethylation at the D17S5 locus is not a frequent event in human urothelial cancer

M. Bernués; C. Casadevall; M. R. Caballín; J. Egozcue; R. Miró

doi:10.1046/j.1464-410X.2002.02892.x

DNA hypermethylation at the D17S5 locus is not a frequent event in human urothelial cancer

M. Bernués, C. Casadevall, M. R. Caballín, J. Egozcue, R. Miró

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Objective: To analyse the DNA methylation status and the loss of heterozygosity (LOH) at the D17S5 locus (17p13.3) in urothelial cancer. Materials and methods: DNA methylation was assayed and LOH analysed by Southern blotting in a series of 33 transitional cell carcinomas of the bladder and renal pelvis. Results: DNA hypermethylation and LOH at the D17S5 locus were detected in six (18%) and 17 (52%) of the tumours, respectively. The six cases with DNA hypermethylation were of the papillary type, and four also had LOH at this locus. Conclusion: In contrast to other epithelial tumours, DNA hypermethylation at the D17S5 locus is not a frequent event in human urothelial cancer.

Idioma original	Anglès
Pàgines (de-a)	332-335
Revista	BJU International
Volum	90
DOIs	https://doi.org/10.1046/j.1464-410X.2002.02892.x
Estat de la publicació	Publicada - 18 de set. 2002

SDG de les Nacions Unides

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10.1046/j.1464-410X.2002.02892.x

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https://www.scopus.com/pages/publications/0036373874

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@article{f98ee8e5751a455eaf2f8b687cb5884e,

title = "DNA hypermethylation at the D17S5 locus is not a frequent event in human urothelial cancer",

abstract = "Objective: To analyse the DNA methylation status and the loss of heterozygosity (LOH) at the D17S5 locus (17p13.3) in urothelial cancer. Materials and methods: DNA methylation was assayed and LOH analysed by Southern blotting in a series of 33 transitional cell carcinomas of the bladder and renal pelvis. Results: DNA hypermethylation and LOH at the D17S5 locus were detected in six (18\%) and 17 (52\%) of the tumours, respectively. The six cases with DNA hypermethylation were of the papillary type, and four also had LOH at this locus. Conclusion: In contrast to other epithelial tumours, DNA hypermethylation at the D17S5 locus is not a frequent event in human urothelial cancer.",

keywords = "DNA methylation, Loss of heterozygosity, Tumour suppressor genes, Urothelial cancer",

author = "M. Bernu{\'e}s and C. Casadevall and Caball{\'i}n, \{M. R.\} and J. Egozcue and R. Mir{\'o}",

year = "2002",

month = sep,

day = "18",

doi = "10.1046/j.1464-410X.2002.02892.x",

language = "English",

volume = "90",

pages = "332--335",

}

TY - JOUR

T1 - DNA hypermethylation at the D17S5 locus is not a frequent event in human urothelial cancer

AU - Bernués, M.

AU - Casadevall, C.

AU - Caballín, M. R.

AU - Egozcue, J.

AU - Miró, R.

PY - 2002/9/18

Y1 - 2002/9/18

N2 - Objective: To analyse the DNA methylation status and the loss of heterozygosity (LOH) at the D17S5 locus (17p13.3) in urothelial cancer. Materials and methods: DNA methylation was assayed and LOH analysed by Southern blotting in a series of 33 transitional cell carcinomas of the bladder and renal pelvis. Results: DNA hypermethylation and LOH at the D17S5 locus were detected in six (18%) and 17 (52%) of the tumours, respectively. The six cases with DNA hypermethylation were of the papillary type, and four also had LOH at this locus. Conclusion: In contrast to other epithelial tumours, DNA hypermethylation at the D17S5 locus is not a frequent event in human urothelial cancer.

AB - Objective: To analyse the DNA methylation status and the loss of heterozygosity (LOH) at the D17S5 locus (17p13.3) in urothelial cancer. Materials and methods: DNA methylation was assayed and LOH analysed by Southern blotting in a series of 33 transitional cell carcinomas of the bladder and renal pelvis. Results: DNA hypermethylation and LOH at the D17S5 locus were detected in six (18%) and 17 (52%) of the tumours, respectively. The six cases with DNA hypermethylation were of the papillary type, and four also had LOH at this locus. Conclusion: In contrast to other epithelial tumours, DNA hypermethylation at the D17S5 locus is not a frequent event in human urothelial cancer.

KW - DNA methylation

KW - Loss of heterozygosity

KW - Tumour suppressor genes

KW - Urothelial cancer

UR - https://www.scopus.com/pages/publications/0036373874

U2 - 10.1046/j.1464-410X.2002.02892.x

DO - 10.1046/j.1464-410X.2002.02892.x

M3 - Article

SN - 1464-4096

VL - 90

SP - 332

EP - 335

JO - BJU International

JF - BJU International

ER -

DNA hypermethylation at the D17S5 locus is not a frequent event in human urothelial cancer

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