TY - JOUR
T1 - Disposition kenetics of tylosin administered intravenously and intramuscularly to pigs
AU - Prats, C.
AU - El Korchi, G.
AU - Francesch, R.
AU - Arboix, M.
AU - Pérez, B.
PY - 2002/1/1
Y1 - 2002/1/1
N2 - The distribution of tylosin was studied using a crossover design, in six pigs following i.v. and i.m. administration of 10 mg kg-1 b.w. Plasma samples were analysed by HPLC and UV absorbance detection. After i.v. administration, t1/2β was 271.3 min, Vd 14.6 L kg-1, Vss 9.7Lkg-1 and CL 26.8 mL min-1 kg-1. After i.m. administration, a Cmax, Of 1 μg mL-1 was reached at 90 min. Mean absorption time was 1988.7 min and bioavailability was 95%. © 2002 Elsevier Science Ltd. All rights reserved.
AB - The distribution of tylosin was studied using a crossover design, in six pigs following i.v. and i.m. administration of 10 mg kg-1 b.w. Plasma samples were analysed by HPLC and UV absorbance detection. After i.v. administration, t1/2β was 271.3 min, Vd 14.6 L kg-1, Vss 9.7Lkg-1 and CL 26.8 mL min-1 kg-1. After i.m. administration, a Cmax, Of 1 μg mL-1 was reached at 90 min. Mean absorption time was 1988.7 min and bioavailability was 95%. © 2002 Elsevier Science Ltd. All rights reserved.
UR - https://www.scopus.com/pages/publications/0036771795
U2 - 10.1016/S0034-5288(02)00036-X
DO - 10.1016/S0034-5288(02)00036-X
M3 - Article
SN - 0034-5288
VL - 73
SP - 141
EP - 144
JO - Research in Veterinary Science
JF - Research in Veterinary Science
ER -