TY - JOUR
T1 - Discrepancy between objective and subjective cognition in major depressive disorder
AU - Goldberg, Ximena
AU - Vicent-Gil, Muriel
AU - Torres, Ivan J.
AU - Navarra-Ventura, Guillem
AU - Figuereo, Inés
AU - Serra-Blasco, Maria
AU - Portella, Maria J.
AU - Aguilar, Eva
AU - Palao, Diego
AU - Lam, Raymond W.
AU - Cardoner, Narcís
AU - Via, Esther
PY - 2019/1/1
Y1 - 2019/1/1
N2 - Objective and subjective cognitive measures are altered in major depressive disorder (MDD), but there is a poor correlation between them. This study aims to explore such discrepancy and the characteristics explaining this phenomenon. 229 patients with MDD subdivided into remitted (n = 57), partially remitted (n = 90) and acute (n = 82) underwent a clinical interview, completed self-report questionnaires and a neuropsychological assessment. The association between objective and subjective cognition was evaluated in the areas of attention and memory. Also, dependent measures of concordance and self-appraisal were calculated for each patient. Potential predictors of these outcomes were evaluated through regression analysis. Depressive symptoms correlated negatively with objective but especially with subjective cognition. Patients in an acute episode showed a significant correlation between objective and subjective attention/memory measures, but also the greatest underestimation of their cognitive performance. In those with fewer depressive symptoms, objective and subjective cognition showed poor correspondence between them. In the regression analyses with the full MDD sample, higher scores on depressive symptoms, intelligence quotient and executive functions predicted lower self-appraisal. Objective and subjective cognition show poor concordance in MDD patients, especially in those with residual mood symptoms. Higher executive functions also explain this discrepancy. Assessments of both subjective cognitive complaints and objective performance seem necessary as they may be measuring different aspects of cognitive functioning.
AB - Objective and subjective cognitive measures are altered in major depressive disorder (MDD), but there is a poor correlation between them. This study aims to explore such discrepancy and the characteristics explaining this phenomenon. 229 patients with MDD subdivided into remitted (n = 57), partially remitted (n = 90) and acute (n = 82) underwent a clinical interview, completed self-report questionnaires and a neuropsychological assessment. The association between objective and subjective cognition was evaluated in the areas of attention and memory. Also, dependent measures of concordance and self-appraisal were calculated for each patient. Potential predictors of these outcomes were evaluated through regression analysis. Depressive symptoms correlated negatively with objective but especially with subjective cognition. Patients in an acute episode showed a significant correlation between objective and subjective attention/memory measures, but also the greatest underestimation of their cognitive performance. In those with fewer depressive symptoms, objective and subjective cognition showed poor correspondence between them. In the regression analyses with the full MDD sample, higher scores on depressive symptoms, intelligence quotient and executive functions predicted lower self-appraisal. Objective and subjective cognition show poor concordance in MDD patients, especially in those with residual mood symptoms. Higher executive functions also explain this discrepancy. Assessments of both subjective cognitive complaints and objective performance seem necessary as they may be measuring different aspects of cognitive functioning.
KW - Self report
KW - Affective disorders
KW - Cognitive functioning
KW - Depression
KW - Neurocognition
UR - http://www.mendeley.com/research/discrepancy-between-objective-subjective-cognition-major-depressive-disorder
U2 - 10.1016/j.euroneuro.2018.11.1104
DO - 10.1016/j.euroneuro.2018.11.1104
M3 - Article
C2 - 30503099
SN - 0924-977X
VL - 29
SP - 46
EP - 56
JO - European Neuropsychopharmacology
JF - European Neuropsychopharmacology
IS - 1
ER -