TY - JOUR
T1 - Differential expression of Kv1.3 and Kv1.5 voltage-dependent K + channels in human skeletal muscle sarcomas
AU - Bielanska, Joanna
AU - Hernández-Losa, Javier
AU - Moline, Teresa
AU - Somoza, Rosa
AU - Ramón Y Cajal, Santiago
AU - Condom, Enric
AU - Ferreres, Joan Carles
AU - Felipe, Antonio
PY - 2012/3/1
Y1 - 2012/3/1
N2 - Because Kv1.3 and Kv1.5 K + channels are remodeled during tumorigenesis and participate in skeletal muscle proliferation, we analyzed their expression in human skeletal muscle sarcomas. Aggressive alveolar rhabdomyosarcoma (ARMS) and embryonal rhabdomyosarcoma (ERMS) were studied. Kv1.5 expression was moderate in adult muscle and low in ERMS, whereas it was notable in ARMS and embryonic samples. Kv1.3 expression showed no major differences between RMS and healthy samples. We found a correlation of Kv1.3 and Kv1.5 expression with the tumor malignancy. © 2012 Informa Healthcare USA, Inc.
AB - Because Kv1.3 and Kv1.5 K + channels are remodeled during tumorigenesis and participate in skeletal muscle proliferation, we analyzed their expression in human skeletal muscle sarcomas. Aggressive alveolar rhabdomyosarcoma (ARMS) and embryonal rhabdomyosarcoma (ERMS) were studied. Kv1.5 expression was moderate in adult muscle and low in ERMS, whereas it was notable in ARMS and embryonic samples. Kv1.3 expression showed no major differences between RMS and healthy samples. We found a correlation of Kv1.3 and Kv1.5 expression with the tumor malignancy. © 2012 Informa Healthcare USA, Inc.
KW - Alveolar rhabdomyosarcomas
KW - Cancer
KW - Embryonal rhabdomyosarcomas
KW - Potassium channels
KW - Skeletal muscle
UR - https://www.scopus.com/pages/publications/84857618618
U2 - 10.3109/07357907.2012.654872
DO - 10.3109/07357907.2012.654872
M3 - Article
SN - 0735-7907
VL - 30
SP - 203
EP - 208
JO - Cancer Investigation
JF - Cancer Investigation
IS - 3
ER -
