Differential effects of chronic treatment with mianserin and protryptiline on rat brain cortical α1-adrenoceptors

Joan Sallés; Enrique Claro; Agustina García; Fernando Picatoste; Albert Badia

doi:10.1016/0006-8993(89)91118-9

Differential effects of chronic treatment with mianserin and protryptiline on rat brain cortical α1-adrenoceptors

Joan Sallés, Enrique Claro, Agustina García, Fernando Picatoste, Albert Badia

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Resum

Chronic administration of mianserin induced an increase in the density of [3H]prazosin binding sites (23%) in membranes and in the maximal noradrenaline stimulation of phosphoinositide breakdown (81%) in slices from rat brain cortex. In contrast, a similar treatment with protryptiline did not induce any significant changes. These findings suggest that the effects of antidepressant drugs on rat braint cortical α1-adrenoceptors may depend on the characteristics of the drug used. © 1989.

Idioma original	Anglès
Pàgines (de-a)	366-370
Revista	Brain Research
Volum	498
DOIs	https://doi.org/10.1016/0006-8993(89)91118-9
Estat de la publicació	Publicada - 2 d’oct. 1989

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10.1016/0006-8993(89)91118-9

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@article{4696bf25e66c4825b9337e432ed24749,

title = "Differential effects of chronic treatment with mianserin and protryptiline on rat brain cortical α1-adrenoceptors",

abstract = "Chronic administration of mianserin induced an increase in the density of [3H]prazosin binding sites (23\%) in membranes and in the maximal noradrenaline stimulation of phosphoinositide breakdown (81\%) in slices from rat brain cortex. In contrast, a similar treatment with protryptiline did not induce any significant changes. These findings suggest that the effects of antidepressant drugs on rat braint cortical α1-adrenoceptors may depend on the characteristics of the drug used. {\textcopyright} 1989.",

keywords = "Adrenoceptor, Cerebral cortex, Mianserin, Phosphoinositide hydrolysis, Prazosin binding, Protryptiline, α 1",

author = "Joan Sall{\'e}s and Enrique Claro and Agustina Garc{\'i}a and Fernando Picatoste and Albert Badia",

year = "1989",

month = oct,

day = "2",

doi = "10.1016/0006-8993(89)91118-9",

language = "English",

volume = "498",

pages = "366--370",

}

TY - JOUR

T1 - Differential effects of chronic treatment with mianserin and protryptiline on rat brain cortical α1-adrenoceptors

AU - Sallés, Joan

AU - Claro, Enrique

AU - García, Agustina

AU - Picatoste, Fernando

AU - Badia, Albert

PY - 1989/10/2

Y1 - 1989/10/2

N2 - Chronic administration of mianserin induced an increase in the density of [3H]prazosin binding sites (23%) in membranes and in the maximal noradrenaline stimulation of phosphoinositide breakdown (81%) in slices from rat brain cortex. In contrast, a similar treatment with protryptiline did not induce any significant changes. These findings suggest that the effects of antidepressant drugs on rat braint cortical α1-adrenoceptors may depend on the characteristics of the drug used. © 1989.

AB - Chronic administration of mianserin induced an increase in the density of [3H]prazosin binding sites (23%) in membranes and in the maximal noradrenaline stimulation of phosphoinositide breakdown (81%) in slices from rat brain cortex. In contrast, a similar treatment with protryptiline did not induce any significant changes. These findings suggest that the effects of antidepressant drugs on rat braint cortical α1-adrenoceptors may depend on the characteristics of the drug used. © 1989.

KW - Adrenoceptor

KW - Cerebral cortex

KW - Mianserin

KW - Phosphoinositide hydrolysis

KW - Prazosin binding

KW - Protryptiline

KW - α 1

UR - https://www.scopus.com/pages/publications/0024414946

U2 - 10.1016/0006-8993(89)91118-9

DO - 10.1016/0006-8993(89)91118-9

M3 - Article

SN - 0006-8993

VL - 498

SP - 366

EP - 370

JO - Brain Research

JF - Brain Research

ER -

Differential effects of chronic treatment with mianserin and protryptiline on rat brain cortical α1-adrenoceptors

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