Developmental toxicity in rat fetuses exposed to the benzimidazole netobimin

Marc Navarro; Lourdes Canut; Ana Carretero; Carles Cristofol; Fco Javier Pérez-Aparicio; Margarida Arboix; Jesús Ruberte

doi:10.1016/S0890-6238(99)00013-1

Developmental toxicity in rat fetuses exposed to the benzimidazole netobimin

Marc Navarro, Lourdes Canut, Ana Carretero, Carles Cristofol, Fco Javier Pérez-Aparicio, Margarida Arboix, Jesús Ruberte

Departament de Farmacologia, de Terapèutica i de Toxicologia

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Netobimin (NTB) is a prodrug of albendazole (ABZ) and is used as a broad-spectrum anthelmintic both in human and veterinary medicine. Pregnant Sprague-Dawley rats were treated po with 50, 59.5 and 70.7 mg/kg of NTB on Gestational Day (GD) 10. The results, observed on GD 20, demonstrated that NTB induced a significant increase of resorptions. Moreover, decreased fetal body weight and an increase in skeletal malformations were observed in treated groups. We report the first study in which vascular malformations are described in rats after the administration of a benzimidazole compound. An interesting relationship between intercostal vessel and rib malformations was found.

Idioma original	Anglès
Pàgines (de-a)	295-302
Revista	Reproductive Toxicology
Volum	13
Número	4
DOIs	https://doi.org/10.1016/S0890-6238(99)00013-1
Estat de la publicació	Publicada - 1 de jul. 1999

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10.1016/S0890-6238(99)00013-1

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@article{34c90b0391914ad9a2f9506261024996,

title = "Developmental toxicity in rat fetuses exposed to the benzimidazole netobimin",

abstract = "Netobimin (NTB) is a prodrug of albendazole (ABZ) and is used as a broad-spectrum anthelmintic both in human and veterinary medicine. Pregnant Sprague-Dawley rats were treated po with 50, 59.5 and 70.7 mg/kg of NTB on Gestational Day (GD) 10. The results, observed on GD 20, demonstrated that NTB induced a significant increase of resorptions. Moreover, decreased fetal body weight and an increase in skeletal malformations were observed in treated groups. We report the first study in which vascular malformations are described in rats after the administration of a benzimidazole compound. An interesting relationship between intercostal vessel and rib malformations was found.",

keywords = "Benzimidazoles, Corrosion casting, Dysmorphogenesis, Embryolethality, Pathogenesis of malformations, Rat fetus, Scanning electron microscopy, Teratology",

author = "Marc Navarro and Lourdes Canut and Ana Carretero and Carles Cristofol and P{\'e}rez-Aparicio, {Fco Javier} and Margarida Arboix and Jes{\'u}s Ruberte",

year = "1999",

month = jul,

day = "1",

doi = "10.1016/S0890-6238(99)00013-1",

language = "English",

volume = "13",

pages = "295--302",

journal = "Reproductive Toxicology",

issn = "0890-6238",

publisher = "Elsevier Inc.",

number = "4",

}

TY - JOUR

T1 - Developmental toxicity in rat fetuses exposed to the benzimidazole netobimin

AU - Navarro, Marc

AU - Canut, Lourdes

AU - Carretero, Ana

AU - Cristofol, Carles

AU - Pérez-Aparicio, Fco Javier

AU - Arboix, Margarida

AU - Ruberte, Jesús

PY - 1999/7/1

Y1 - 1999/7/1

N2 - Netobimin (NTB) is a prodrug of albendazole (ABZ) and is used as a broad-spectrum anthelmintic both in human and veterinary medicine. Pregnant Sprague-Dawley rats were treated po with 50, 59.5 and 70.7 mg/kg of NTB on Gestational Day (GD) 10. The results, observed on GD 20, demonstrated that NTB induced a significant increase of resorptions. Moreover, decreased fetal body weight and an increase in skeletal malformations were observed in treated groups. We report the first study in which vascular malformations are described in rats after the administration of a benzimidazole compound. An interesting relationship between intercostal vessel and rib malformations was found.

AB - Netobimin (NTB) is a prodrug of albendazole (ABZ) and is used as a broad-spectrum anthelmintic both in human and veterinary medicine. Pregnant Sprague-Dawley rats were treated po with 50, 59.5 and 70.7 mg/kg of NTB on Gestational Day (GD) 10. The results, observed on GD 20, demonstrated that NTB induced a significant increase of resorptions. Moreover, decreased fetal body weight and an increase in skeletal malformations were observed in treated groups. We report the first study in which vascular malformations are described in rats after the administration of a benzimidazole compound. An interesting relationship between intercostal vessel and rib malformations was found.

KW - Benzimidazoles

KW - Corrosion casting

KW - Dysmorphogenesis

KW - Embryolethality

KW - Pathogenesis of malformations

KW - Rat fetus

KW - Scanning electron microscopy

KW - Teratology

U2 - 10.1016/S0890-6238(99)00013-1

DO - 10.1016/S0890-6238(99)00013-1

M3 - Article

SN - 0890-6238

VL - 13

SP - 295

EP - 302

JO - Reproductive Toxicology

JF - Reproductive Toxicology

IS - 4

ER -

Developmental toxicity in rat fetuses exposed to the benzimidazole netobimin

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