Determination of ascorbic acid in pharmaceutical preparations by near infrared reflectance spectroscopy

M. Blanco, J. Coello, H. Iturriaga, S. Maspoch, C. de la Pezuela

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Resum

We developed a method for determination of ascorbic acid in pharmaceutical preparations containing various excipients by using near infrared diffuse reflectance spectroscopy and two different calibration methods, viz. stepwise multiple linear regression (SMLR) and partial least-squares (PLS) regression, which provided comparable results and resulted in prediction errors of 1-2%. However, the PLS method provided somewhat better results with the more complex samples. © 1993.
Idioma originalEnglish
Pàgines (de-a)1671-1676
RevistaTalanta
Volum40
Número11
DOIs
Estat de la publicacióPublicada - 1 de gen. 1993

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