Detection of Viruses and Virus-Neutralizing Antibodies Using Synthetic Erythrocytes: Toward a Tuneable Tool for Virus Surveillance

Ana Sánchez-Cano, Cristina Andrés, José R. Herance, Tomás Pumarola, Andrés Antón, Eva Baldrich*

*Autor corresponent d’aquest treball

Producció científica: Contribució a revistaArticleRecercaAvaluat per experts

2 Cites (Scopus)

Resum

The hemagglutination inhibition assay (HAI) is a classical method used worldwide in many analytical applications, including pathogen identification, vaccine production monitoring, and detection and characterization of pathogen-neutralizing antibodies (n-Ab). This is also a World Health Organization (WHO) reference method for the global surveillance of influenza viruses, which provides the information needed for the annual reformulation of the flu vaccine. HAI is a simple and inexpensive method that is performed without sophisticated equipment. However, it has to be carried out with fresh red blood cells (RBCs), a highly variable, unstable, and hard to mass-produce reagent, which impairs assay reproducibility. Here, we used the tests employed for influenza surveillance as a model to develop synthrocytes.
Idioma originalAnglès
Pàgines (de-a)83-90
Nombre de pàgines8
RevistaACS Sensors
Volum6
Número1
DOIs
Estat de la publicacióPublicada - 11 de gen. 2021
Publicat externament

Fingerprint

Navegar pels temes de recerca de 'Detection of Viruses and Virus-Neutralizing Antibodies Using Synthetic Erythrocytes: Toward a Tuneable Tool for Virus Surveillance'. Junts formen un fingerprint únic.

Com citar-ho