@article{2d2d5b1676a64c8ebb8aa7ec33f5967c,
title = "Design and synthesis of S-(-)-2-[[4-(napht-1-yl)piperazin-1-yl]methyl]-1,4-dioxoperhydropyrrolo[1,2- a]pyrazine (CSP-2503) using computational simulation. A 5-HT1A receptor agonist",
abstract = "Based on a computational model for 5-HT1AR-ligand interaction and QSAR studies, we have designed and synthesized a new series of arylpiperazines 2-8 which exhibit high 5-HT1AR affinity and selectivity over α1-adrenergic receptors. Among them, compound CSP-2503 (4) has been pharmacologically characterized as a 5-HT1AR agonist at somatodendritic and postsynaptic sites, endowed with anxiolytic properties. {\textcopyright} 2003 Elsevier Science Ltd. All rights reserved.",
author = "L{\'o}pez-Rodr{\'i}guez, {Mar{\'i}a L.} and Morcillo, {Ma Jos{\'e}} and Esther Fern{\'a}ndez and Bellinda Benham{\'u} and Ignacio Tejada and David Ayala and Alma Viso and Mireia Olivella and Leonardo Pardo and Mercedes Delgado and Jorge Manzanares and Fuentes, {Jos{\'e} A.}",
year = "2003",
month = apr,
day = "17",
doi = "10.1016/S0960-894X(03)00160-4",
language = "English",
volume = "13",
pages = "1429--1432",
journal = "Bioorganic and Medicinal Chemistry Letters",
issn = "0960-894X",
publisher = "Elsevier Limited",
number = "8",
}