Decreased CX3CL1 levels in the cerebrospinal fluid of patients with Alzheimer's disease

Juan R. Perea; Alberto Lleó; Daniel Alcolea; Juan Fortea; Jesús Ávila; Marta Bolós

doi:10.3389/fnins.2018.00609

Decreased CX3CL1 levels in the cerebrospinal fluid of patients with Alzheimer's disease

Juan R. Perea, Alberto Lleó, Daniel Alcolea, Juan Fortea, Jesús Ávila, Marta Bolós

Departament de Medicina

Producció científica: Contribució a revista › Article › Recerca

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© 2018 Perea, Lleó, Alcolea, Fortea, ávila and Bolós. Alzheimer's disease (AD) is a neurodegenerative disease characterized by the presence of neurofibrillary tangles, constituted by tau protein, and plaques formed by amyloid-beta protein. The disease courses with high neural damage, which leads to memory loss and death. Here we analyzed the presence of CX3CL1, a chemokine expressed by neurons, in cerebrospinal fluid (CSF) samples from control subjects and patients with mild cognitive impairment and AD dementia. CX3CL1 was decreased in the CSF of AD dementia patients compared to control subjects. However, there was not difference in plasma samples from the same subjects.

Idioma original	Anglès
Número d’article	609
Revista	Frontiers in Neuroscience
Volum	12
DOIs	https://doi.org/10.3389/fnins.2018.00609
Estat de la publicació	Publicada - 7 de set. 2018

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10.3389/fnins.2018.00609

https://ddd.uab.cat/record/253654

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title = "Decreased CX3CL1 levels in the cerebrospinal fluid of patients with Alzheimer's disease",

abstract = "{\textcopyright} 2018 Perea, Lle{\'o}, Alcolea, Fortea, {\'a}vila and Bol{\'o}s. Alzheimer's disease (AD) is a neurodegenerative disease characterized by the presence of neurofibrillary tangles, constituted by tau protein, and plaques formed by amyloid-beta protein. The disease courses with high neural damage, which leads to memory loss and death. Here we analyzed the presence of CX3CL1, a chemokine expressed by neurons, in cerebrospinal fluid (CSF) samples from control subjects and patients with mild cognitive impairment and AD dementia. CX3CL1 was decreased in the CSF of AD dementia patients compared to control subjects. However, there was not difference in plasma samples from the same subjects.",

keywords = "Alzheimer's disease, CX3CL1, Human CSF, Inflammation, Microglia, Tau",

author = "Perea, {Juan R.} and Alberto Lle{\'o} and Daniel Alcolea and Juan Fortea and Jes{\'u}s {\'A}vila and Marta Bol{\'o}s",

year = "2018",

month = sep,

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doi = "10.3389/fnins.2018.00609",

language = "English",

volume = "12",

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TY - JOUR

T1 - Decreased CX3CL1 levels in the cerebrospinal fluid of patients with Alzheimer's disease

AU - Perea, Juan R.

AU - Lleó, Alberto

AU - Alcolea, Daniel

AU - Fortea, Juan

AU - Ávila, Jesús

AU - Bolós, Marta

PY - 2018/9/7

Y1 - 2018/9/7

N2 - © 2018 Perea, Lleó, Alcolea, Fortea, ávila and Bolós. Alzheimer's disease (AD) is a neurodegenerative disease characterized by the presence of neurofibrillary tangles, constituted by tau protein, and plaques formed by amyloid-beta protein. The disease courses with high neural damage, which leads to memory loss and death. Here we analyzed the presence of CX3CL1, a chemokine expressed by neurons, in cerebrospinal fluid (CSF) samples from control subjects and patients with mild cognitive impairment and AD dementia. CX3CL1 was decreased in the CSF of AD dementia patients compared to control subjects. However, there was not difference in plasma samples from the same subjects.

AB - © 2018 Perea, Lleó, Alcolea, Fortea, ávila and Bolós. Alzheimer's disease (AD) is a neurodegenerative disease characterized by the presence of neurofibrillary tangles, constituted by tau protein, and plaques formed by amyloid-beta protein. The disease courses with high neural damage, which leads to memory loss and death. Here we analyzed the presence of CX3CL1, a chemokine expressed by neurons, in cerebrospinal fluid (CSF) samples from control subjects and patients with mild cognitive impairment and AD dementia. CX3CL1 was decreased in the CSF of AD dementia patients compared to control subjects. However, there was not difference in plasma samples from the same subjects.

KW - Alzheimer's disease

KW - CX3CL1

KW - Human CSF

KW - Inflammation

KW - Microglia

KW - Tau

U2 - 10.3389/fnins.2018.00609

DO - 10.3389/fnins.2018.00609

M3 - Article

C2 - 30245615

SN - 1662-4548

VL - 12

JO - Frontiers in Neuroscience

JF - Frontiers in Neuroscience

M1 - 609

ER -

Decreased CX3CL1 levels in the cerebrospinal fluid of patients with Alzheimer's disease

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