Cytogenetic effects of radiotherapy: Frequency and types of chromosome aberrations

Leonardo Barrios; Maria Rosa Caballín; Rosa Miró; Carme Fuster; Ferràn Guedea; Antoni Subias; Josep Egozcue

doi:10.1016/0360-3016(90)90546-V

Cytogenetic effects of radiotherapy: Frequency and types of chromosome aberrations

Leonardo Barrios, Maria Rosa Caballín, Rosa Miró, Carme Fuster, Ferràn Guedea, Antoni Subias, Josep Egozcue

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The frequency and types of chromosome aberrations induced by ionizing radiation in cancer patients were evaluated in 24 cases studied just before and immediately after radiotherapy. The incidence of aberrant metaphases prior to treatment was 9.913% and increased significantly after treatment to 32.8%. The frequency of chromosome aberrations before radiotherapy was, with the exception of the cases of breast cancer and seminoma, significantly higher than that in our laboratory controls. A comparison of chromosome abnormalities observed before and after treatment indicated that dicentric translocations, rings, and reciprocal translocations increased by a factor of 23, 13, and 11, respectively, after radiotherapy. Ionizing radiation produces more asymmetrical than symmetrical chromosome aberrations and more two-break than one-break anomalies. © 1990.

Idioma original	Anglès
Pàgines (de-a)	371-375
Revista	International Journal of Radiation Oncology, Biology, Physics
Volum	19
DOIs	https://doi.org/10.1016/0360-3016(90)90546-V
Estat de la publicació	Publicada - 1 de gen. 1990

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10.1016/0360-3016(90)90546-V

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title = "Cytogenetic effects of radiotherapy: Frequency and types of chromosome aberrations",

abstract = "The frequency and types of chromosome aberrations induced by ionizing radiation in cancer patients were evaluated in 24 cases studied just before and immediately after radiotherapy. The incidence of aberrant metaphases prior to treatment was 9.913% and increased significantly after treatment to 32.8%. The frequency of chromosome aberrations before radiotherapy was, with the exception of the cases of breast cancer and seminoma, significantly higher than that in our laboratory controls. A comparison of chromosome abnormalities observed before and after treatment indicated that dicentric translocations, rings, and reciprocal translocations increased by a factor of 23, 13, and 11, respectively, after radiotherapy. Ionizing radiation produces more asymmetrical than symmetrical chromosome aberrations and more two-break than one-break anomalies. {\textcopyright} 1990.",

keywords = "Chromosome aberrations, Radiotherapy",

author = "Leonardo Barrios and Caball{\'i}n, {Maria Rosa} and Rosa Mir{\'o} and Carme Fuster and Ferr{\`a}n Guedea and Antoni Subias and Josep Egozcue",

year = "1990",

month = jan,

day = "1",

doi = "10.1016/0360-3016(90)90546-V",

language = "English",

volume = "19",

pages = "371--375",

journal = "International Journal of Radiation Oncology, Biology, Physics",

issn = "0360-3016",

publisher = "Elsevier Inc.",

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TY - JOUR

T1 - Cytogenetic effects of radiotherapy: Frequency and types of chromosome aberrations

AU - Barrios, Leonardo

AU - Caballín, Maria Rosa

AU - Miró, Rosa

AU - Fuster, Carme

AU - Guedea, Ferràn

AU - Subias, Antoni

AU - Egozcue, Josep

PY - 1990/1/1

Y1 - 1990/1/1

N2 - The frequency and types of chromosome aberrations induced by ionizing radiation in cancer patients were evaluated in 24 cases studied just before and immediately after radiotherapy. The incidence of aberrant metaphases prior to treatment was 9.913% and increased significantly after treatment to 32.8%. The frequency of chromosome aberrations before radiotherapy was, with the exception of the cases of breast cancer and seminoma, significantly higher than that in our laboratory controls. A comparison of chromosome abnormalities observed before and after treatment indicated that dicentric translocations, rings, and reciprocal translocations increased by a factor of 23, 13, and 11, respectively, after radiotherapy. Ionizing radiation produces more asymmetrical than symmetrical chromosome aberrations and more two-break than one-break anomalies. © 1990.

AB - The frequency and types of chromosome aberrations induced by ionizing radiation in cancer patients were evaluated in 24 cases studied just before and immediately after radiotherapy. The incidence of aberrant metaphases prior to treatment was 9.913% and increased significantly after treatment to 32.8%. The frequency of chromosome aberrations before radiotherapy was, with the exception of the cases of breast cancer and seminoma, significantly higher than that in our laboratory controls. A comparison of chromosome abnormalities observed before and after treatment indicated that dicentric translocations, rings, and reciprocal translocations increased by a factor of 23, 13, and 11, respectively, after radiotherapy. Ionizing radiation produces more asymmetrical than symmetrical chromosome aberrations and more two-break than one-break anomalies. © 1990.

KW - Chromosome aberrations

KW - Radiotherapy

U2 - 10.1016/0360-3016(90)90546-V

DO - 10.1016/0360-3016(90)90546-V

M3 - Article

SN - 0360-3016

VL - 19

SP - 371

EP - 375

JO - International Journal of Radiation Oncology, Biology, Physics

JF - International Journal of Radiation Oncology, Biology, Physics

ER -

Cytogenetic effects of radiotherapy: Frequency and types of chromosome aberrations

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