TY - JOUR
T1 - Copper complex protection in the regioselective alkylation of methyl 3,5-dioxohexanoate. Preparation of 3-alkyl derivatives of 4-hydroxy-6-methyl-2-pyrone
AU - Cervello, Jordi
AU - Marquet, Jorge
AU - Moreno-Mañas, Marcial
PY - 1987/1/1
Y1 - 1987/1/1
N2 - Protection of the diketone moiety of the polyketide model methyl 3,5-dioxohexanoate by copper(II) complex formation followed by alkylation of the free C-2 position results in overall regioselective alkylation of the diketoester to afford methyl 2-alkyl-3,5-dioxohexanoates, which under cyclization afford 3-alkyl derivatives of triacetic acid lactone. © 1987.
AB - Protection of the diketone moiety of the polyketide model methyl 3,5-dioxohexanoate by copper(II) complex formation followed by alkylation of the free C-2 position results in overall regioselective alkylation of the diketoester to afford methyl 2-alkyl-3,5-dioxohexanoates, which under cyclization afford 3-alkyl derivatives of triacetic acid lactone. © 1987.
U2 - 10.1016/S0040-4039(00)96365-2
DO - 10.1016/S0040-4039(00)96365-2
M3 - Article
SN - 0040-4039
VL - 28
SP - 3715
EP - 3716
JO - Tetrahedron Letters
JF - Tetrahedron Letters
IS - 32
ER -