TY - JOUR
T1 - Contact sensitization to limonene and linalool hydroperoxides in Spain: a GEIDAC* prospective study
AU - Deza, Gustavo
AU - García-Bravo, Begoña
AU - Silvestre, Juan F.
AU - Pastor-Nieto, Maria A.
AU - González-Pérez, Ricardo
AU - Heras-Mendaza, Felipe
AU - Mercader, Pedro
AU - Fernández-Redondo, Virginia
AU - Niklasson, Bo
AU - Giménez-Arnau, Ana M.
AU - Hita, J. Armario
AU - Hernando, L. Borrego
AU - Carrillo, J. Carrascosa
AU - Guijarro, S. Córdoba
AU - Gavín, J. García
AU - Ortega, M. Gattica
AU - de la Fuente, J. Gómez
AU - Hervella Garcés, M.
AU - de Frutos, J. Ortiz
AU - Rodríguez Serna, M.
AU - Ruíz González, I.
AU - Sánchez Pedreño, P.
AU - Sánchez Pérez, J.
AU - Baldrich, E. Serra
AU - Hita, J. Armario
AU - Hernando, L. Borrego
AU - Carrillo, J. Carrascosa
AU - Guijarro, S. Córdoba
AU - Gavín, J. García
AU - Ortega, M. Gattica
AU - de la Fuente, J. Gómez
AU - Garcés, M. Hervella
AU - de Frutos, J. Ortiz
AU - Serna, M. Rodríguez
AU - González, I. Ruíz
AU - Pedreño, P. Sánchez
AU - Pérez, J. Sánchez
AU - Baldrich, E. Serra
PY - 2017/2/1
Y1 - 2017/2/1
N2 - © 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd Background: Limonene and linalool are common fragrance terpenes widely used in cosmetic, household and hygiene products. Their primary oxidation products formed after air exposure, the hydroperoxides, have been recognized as important contact haptens. Objectives: To investigate the prevalence of contact allergy to hydroperoxides of limonene (Lim-OOHs) and hydroperoxides of linalool (Lin-OOHs) in Spain, and to define the optimal concentration for screening in consecutive patients. Methods: Three different concentrations of Lim-OOHs (0.1%, 0.2% and 0.3% pet.) and Lin-OOHs (0.25%, 0.5% and 1.0% pet.) were simultaneously tested in 3639 consecutive patients at 22 departments of dermatology in Spain. Results: Lim-OOHs at 0.1%, 0.2% and 0.3% yielded positive patch test reactions in 1.4%, 3.4% and 5.1% of the tested patients, respectively; and Lin-OOHs at 0.25%, 0.5% and 1.0% yielded positive reactions in 1.3%, 2.9% and 4.9% of the tested patients, respectively. Few irritant (1.5–1.9%) and doubtful reactions (0.4–0.5%) to both terpene hydroperoxides were registered at the highest concentrations tested. Conclusions: Lim-OOHs and Lin-OOHs can be considered as common causes of contact allergy, and their inclusion in an extended baseline patch test series therefore seems to be appropriate. The patch test preparations of Lim-OOHs 0.3% pet. and Lin-OOHs 1.0% pet. are useful tools for screening of contact sensitization.
AB - © 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd Background: Limonene and linalool are common fragrance terpenes widely used in cosmetic, household and hygiene products. Their primary oxidation products formed after air exposure, the hydroperoxides, have been recognized as important contact haptens. Objectives: To investigate the prevalence of contact allergy to hydroperoxides of limonene (Lim-OOHs) and hydroperoxides of linalool (Lin-OOHs) in Spain, and to define the optimal concentration for screening in consecutive patients. Methods: Three different concentrations of Lim-OOHs (0.1%, 0.2% and 0.3% pet.) and Lin-OOHs (0.25%, 0.5% and 1.0% pet.) were simultaneously tested in 3639 consecutive patients at 22 departments of dermatology in Spain. Results: Lim-OOHs at 0.1%, 0.2% and 0.3% yielded positive patch test reactions in 1.4%, 3.4% and 5.1% of the tested patients, respectively; and Lin-OOHs at 0.25%, 0.5% and 1.0% yielded positive reactions in 1.3%, 2.9% and 4.9% of the tested patients, respectively. Few irritant (1.5–1.9%) and doubtful reactions (0.4–0.5%) to both terpene hydroperoxides were registered at the highest concentrations tested. Conclusions: Lim-OOHs and Lin-OOHs can be considered as common causes of contact allergy, and their inclusion in an extended baseline patch test series therefore seems to be appropriate. The patch test preparations of Lim-OOHs 0.3% pet. and Lin-OOHs 1.0% pet. are useful tools for screening of contact sensitization.
KW - allergic contact dermatitis
KW - fragrance allergy
KW - hydroperoxides
KW - limonene
KW - linalool
U2 - 10.1111/cod.12714
DO - 10.1111/cod.12714
M3 - Article
SN - 0105-1873
VL - 76
SP - 74
EP - 80
JO - Contact Dermatitis
JF - Contact Dermatitis
IS - 2
ER -