TY - JOUR
T1 - Comprehensive embryo analysis of advanced maternal age-related aneuploidies and mosaicism by short comparative genomic hybridization
AU - Rius, Mariona
AU - Daina, Gemma
AU - Obradors, Albert
AU - Ramos, Laia
AU - Velilla, Esther
AU - Fernández, Sílvia
AU - Martínez-Passarell, Olga
AU - Benet, Jordi
AU - Navarro, Joaquima
PY - 2011/1/1
Y1 - 2011/1/1
N2 - The short comparative genomic hybridization (short-CGH) method was used to perform a comprehensive cytogenetic study of isolated blastomeres from advanced maternal age embryos, discarded after fluorescent in situ hybridization (FISH) preimplantation genetic screening (PGS), detecting aneuploidies (38.5% of which corresponded to chromosomes not screened by 9-chromosome FISH), structural aberrations (31.8%), and mosaicism (77.3%). The short-CGH method was subsequently applied in one PGS, achieving a twin pregnancy. © 2011 American Society for Reproductive Medicine, Published by Elsevier Inc.
AB - The short comparative genomic hybridization (short-CGH) method was used to perform a comprehensive cytogenetic study of isolated blastomeres from advanced maternal age embryos, discarded after fluorescent in situ hybridization (FISH) preimplantation genetic screening (PGS), detecting aneuploidies (38.5% of which corresponded to chromosomes not screened by 9-chromosome FISH), structural aberrations (31.8%), and mosaicism (77.3%). The short-CGH method was subsequently applied in one PGS, achieving a twin pregnancy. © 2011 American Society for Reproductive Medicine, Published by Elsevier Inc.
KW - CGH
KW - chromosome abnormality
KW - FISH
KW - mosaicism
KW - PGS
UR - https://www.scopus.com/pages/publications/78650416518
U2 - 10.1016/j.fertnstert.2010.07.1051
DO - 10.1016/j.fertnstert.2010.07.1051
M3 - Article
SN - 0015-0282
VL - 95
SP - 413
EP - 416
JO - Fertility and Sterility
JF - Fertility and Sterility
IS - 1
ER -