Comprehensive embryo analysis of advanced maternal age-related aneuploidies and mosaicism by short comparative genomic hybridization

Mariona Rius; Gemma Daina; Albert Obradors; Laia Ramos; Esther Velilla; Sílvia Fernández; Olga Martínez-Passarell; Jordi Benet; Joaquima Navarro

doi:10.1016/j.fertnstert.2010.07.1051

Comprehensive embryo analysis of advanced maternal age-related aneuploidies and mosaicism by short comparative genomic hybridization

Mariona Rius, Gemma Daina, Albert Obradors, Laia Ramos, Esther Velilla, Sílvia Fernández, Olga Martínez-Passarell, Jordi Benet, Joaquima Navarro

Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia

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The short comparative genomic hybridization (short-CGH) method was used to perform a comprehensive cytogenetic study of isolated blastomeres from advanced maternal age embryos, discarded after fluorescent in situ hybridization (FISH) preimplantation genetic screening (PGS), detecting aneuploidies (38.5% of which corresponded to chromosomes not screened by 9-chromosome FISH), structural aberrations (31.8%), and mosaicism (77.3%). The short-CGH method was subsequently applied in one PGS, achieving a twin pregnancy. © 2011 American Society for Reproductive Medicine, Published by Elsevier Inc.

Idioma original	Anglès
Pàgines (de-a)	413-416
Revista	Fertility and Sterility
Volum	95
Número	1
DOIs	https://doi.org/10.1016/j.fertnstert.2010.07.1051
Estat de la publicació	Publicada - 1 de gen. 2011

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10.1016/j.fertnstert.2010.07.1051

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title = "Comprehensive embryo analysis of advanced maternal age-related aneuploidies and mosaicism by short comparative genomic hybridization",

abstract = "The short comparative genomic hybridization (short-CGH) method was used to perform a comprehensive cytogenetic study of isolated blastomeres from advanced maternal age embryos, discarded after fluorescent in situ hybridization (FISH) preimplantation genetic screening (PGS), detecting aneuploidies (38.5% of which corresponded to chromosomes not screened by 9-chromosome FISH), structural aberrations (31.8%), and mosaicism (77.3%). The short-CGH method was subsequently applied in one PGS, achieving a twin pregnancy. {\textcopyright} 2011 American Society for Reproductive Medicine, Published by Elsevier Inc.",

keywords = "CGH, chromosome abnormality, FISH, mosaicism, PGS",

author = "Mariona Rius and Gemma Daina and Albert Obradors and Laia Ramos and Esther Velilla and S{\'i}lvia Fern{\'a}ndez and Olga Mart{\'i}nez-Passarell and Jordi Benet and Joaquima Navarro",

year = "2011",

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doi = "10.1016/j.fertnstert.2010.07.1051",

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T1 - Comprehensive embryo analysis of advanced maternal age-related aneuploidies and mosaicism by short comparative genomic hybridization

AU - Rius, Mariona

AU - Daina, Gemma

AU - Obradors, Albert

AU - Ramos, Laia

AU - Velilla, Esther

AU - Fernández, Sílvia

AU - Martínez-Passarell, Olga

AU - Benet, Jordi

AU - Navarro, Joaquima

PY - 2011/1/1

Y1 - 2011/1/1

N2 - The short comparative genomic hybridization (short-CGH) method was used to perform a comprehensive cytogenetic study of isolated blastomeres from advanced maternal age embryos, discarded after fluorescent in situ hybridization (FISH) preimplantation genetic screening (PGS), detecting aneuploidies (38.5% of which corresponded to chromosomes not screened by 9-chromosome FISH), structural aberrations (31.8%), and mosaicism (77.3%). The short-CGH method was subsequently applied in one PGS, achieving a twin pregnancy. © 2011 American Society for Reproductive Medicine, Published by Elsevier Inc.

AB - The short comparative genomic hybridization (short-CGH) method was used to perform a comprehensive cytogenetic study of isolated blastomeres from advanced maternal age embryos, discarded after fluorescent in situ hybridization (FISH) preimplantation genetic screening (PGS), detecting aneuploidies (38.5% of which corresponded to chromosomes not screened by 9-chromosome FISH), structural aberrations (31.8%), and mosaicism (77.3%). The short-CGH method was subsequently applied in one PGS, achieving a twin pregnancy. © 2011 American Society for Reproductive Medicine, Published by Elsevier Inc.

KW - CGH

KW - chromosome abnormality

KW - FISH

KW - mosaicism

KW - PGS

U2 - 10.1016/j.fertnstert.2010.07.1051

DO - 10.1016/j.fertnstert.2010.07.1051

M3 - Article

SN - 0015-0282

VL - 95

SP - 413

EP - 416

JO - Fertility and Sterility

JF - Fertility and Sterility

IS - 1

ER -

Comprehensive embryo analysis of advanced maternal age-related aneuploidies and mosaicism by short comparative genomic hybridization

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