Comparison of two commercially available gamma interferon blood tests for immunodiagnosis of tuberculosis

Jose Domínguez; Juan Ruiz-Manzano; Malú De Souza-Galvão; Irene Latorre; Celia Milà; Silvia Blanco; M. Ángeles Jiménez; Cristina Prat; Alicia Lacoma; Neus Altet; Vicente Ausina

doi:10.1128/CVI.00364-07

Comparison of two commercially available gamma interferon blood tests for immunodiagnosis of tuberculosis

Jose Domínguez, Juan Ruiz-Manzano, Malú De Souza-Galvão, Irene Latorre, Celia Milà, Silvia Blanco, M. Ángeles Jiménez, Cristina Prat, Alicia Lacoma, Neus Altet, Vicente Ausina

Departament de Genètica i de Microbiologia

Producció científica: Contribució a revista › Article › Recerca › Avaluat per experts

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Resum

We evaluated the T-SPOT.TB and Quantiferon-TB Gold In tube (QFN-G-IT) tests for diagnosing Mycobacterium tuberculosis infection. T-SPOT.TB was more sensitive than QFN-G-IT in diagnosing both active and latent infection. Both gamma interferon tests were unaffected by prior Mycobacterium bovis BCG vaccination. Among children who were not BCG vaccinated but had a positive tuberculin skin test, QFN-G-IT was negative in 53.3% of cases, and T-SPOT.TB was negative in 50% of cases. Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Idioma original	Anglès
Pàgines (de-a)	168-171
Revista	Clinical and Vaccine Immunology
Volum	15
Número	1
DOIs	https://doi.org/10.1128/CVI.00364-07
Estat de la publicació	Publicada - 1 de gen. 2008

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10.1128/CVI.00364-07

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title = "Comparison of two commercially available gamma interferon blood tests for immunodiagnosis of tuberculosis",

abstract = "We evaluated the T-SPOT.TB and Quantiferon-TB Gold In tube (QFN-G-IT) tests for diagnosing Mycobacterium tuberculosis infection. T-SPOT.TB was more sensitive than QFN-G-IT in diagnosing both active and latent infection. Both gamma interferon tests were unaffected by prior Mycobacterium bovis BCG vaccination. Among children who were not BCG vaccinated but had a positive tuberculin skin test, QFN-G-IT was negative in 53.3% of cases, and T-SPOT.TB was negative in 50% of cases. Copyright {\textcopyright} 2008, American Society for Microbiology. All Rights Reserved.",

author = "Jose Dom{\'i}nguez and Juan Ruiz-Manzano and {De Souza-Galv{\~a}o}, Mal{\'u} and Irene Latorre and Celia Mil{\`a} and Silvia Blanco and Jim{\'e}nez, {M. {\'A}ngeles} and Cristina Prat and Alicia Lacoma and Neus Altet and Vicente Ausina",

year = "2008",

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doi = "10.1128/CVI.00364-07",

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T1 - Comparison of two commercially available gamma interferon blood tests for immunodiagnosis of tuberculosis

AU - Domínguez, Jose

AU - Ruiz-Manzano, Juan

AU - De Souza-Galvão, Malú

AU - Latorre, Irene

AU - Milà, Celia

AU - Blanco, Silvia

AU - Jiménez, M. Ángeles

AU - Prat, Cristina

AU - Lacoma, Alicia

AU - Altet, Neus

AU - Ausina, Vicente

PY - 2008/1/1

Y1 - 2008/1/1

N2 - We evaluated the T-SPOT.TB and Quantiferon-TB Gold In tube (QFN-G-IT) tests for diagnosing Mycobacterium tuberculosis infection. T-SPOT.TB was more sensitive than QFN-G-IT in diagnosing both active and latent infection. Both gamma interferon tests were unaffected by prior Mycobacterium bovis BCG vaccination. Among children who were not BCG vaccinated but had a positive tuberculin skin test, QFN-G-IT was negative in 53.3% of cases, and T-SPOT.TB was negative in 50% of cases. Copyright © 2008, American Society for Microbiology. All Rights Reserved.

AB - We evaluated the T-SPOT.TB and Quantiferon-TB Gold In tube (QFN-G-IT) tests for diagnosing Mycobacterium tuberculosis infection. T-SPOT.TB was more sensitive than QFN-G-IT in diagnosing both active and latent infection. Both gamma interferon tests were unaffected by prior Mycobacterium bovis BCG vaccination. Among children who were not BCG vaccinated but had a positive tuberculin skin test, QFN-G-IT was negative in 53.3% of cases, and T-SPOT.TB was negative in 50% of cases. Copyright © 2008, American Society for Microbiology. All Rights Reserved.

U2 - 10.1128/CVI.00364-07

DO - 10.1128/CVI.00364-07

M3 - Article

SN - 1556-6811

VL - 15

SP - 168

EP - 171

JO - Clinical and Vaccine Immunology

JF - Clinical and Vaccine Immunology

IS - 1

ER -

Comparison of two commercially available gamma interferon blood tests for immunodiagnosis of tuberculosis

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