TY - JOUR
T1 - Common pathways in dementia and diabetic retinopathy
T2 - understanding the mechanisms of diabetes-related cognitive decline
AU - Little, Karis
AU - Llorián-Salvador, María
AU - Scullion, Sarah
AU - Hernández, Cristina
AU - Simó-Servat, Olga
AU - Del Marco, Angel
AU - Bosma, Esmeralda
AU - Vargas-Soria, Maria
AU - Carranza-Naval, Maria Jose
AU - Van Bergen, Tine
AU - Galbiati, Silvia
AU - Viganò, Ilaria
AU - Musi, Clara Alice
AU - Schlingemann, Reiner
AU - Feyen, Jean
AU - Borsello, Tiziana
AU - Zerbini, Gianpaolo
AU - Klaassen, Ingeborg
AU - Garcia-Alloza, Monica
AU - Simó, Rafael
AU - Stitt, Alan W
N1 - Copyright © 2021. Published by Elsevier Ltd.
PY - 2022/1
Y1 - 2022/1
N2 - Type 2 diabetes (T2D) is associated with multiple comorbidities, including diabetic retinopathy (DR) and cognitive decline, and T2D patients have a significantly higher risk of developing Alzheimer's disease (AD). Both DR and AD are characterized by a number of pathological mechanisms that coalesce around the neurovascular unit, including neuroinflammation and degeneration, vascular degeneration, and glial activation. Chronic hyperglycemia and insulin resistance also play a significant role, leading to activation of pathological mechanisms such as increased oxidative stress and the accumulation of advanced glycation end-products (AGEs). Understanding these common pathways and the degree to which they occur simultaneously in the brain and retina during diabetes will provide avenues to identify T2D patients at risk of cognitive decline.
AB - Type 2 diabetes (T2D) is associated with multiple comorbidities, including diabetic retinopathy (DR) and cognitive decline, and T2D patients have a significantly higher risk of developing Alzheimer's disease (AD). Both DR and AD are characterized by a number of pathological mechanisms that coalesce around the neurovascular unit, including neuroinflammation and degeneration, vascular degeneration, and glial activation. Chronic hyperglycemia and insulin resistance also play a significant role, leading to activation of pathological mechanisms such as increased oxidative stress and the accumulation of advanced glycation end-products (AGEs). Understanding these common pathways and the degree to which they occur simultaneously in the brain and retina during diabetes will provide avenues to identify T2D patients at risk of cognitive decline.
KW - Alzheimer Disease/metabolism
KW - Cognitive Dysfunction/etiology
KW - Diabetes Mellitus, Type 2/complications
KW - Diabetic Retinopathy/metabolism
KW - Glycation End Products, Advanced/metabolism
KW - Humans
KW - Diabetes
KW - Cognitive decline
KW - Alzheimer's disease
KW - Neurovascular unit
U2 - 10.1016/j.tem.2021.10.008
DO - 10.1016/j.tem.2021.10.008
M3 - Review article
C2 - 34794851
SN - 1043-2760
VL - 33
SP - 50
EP - 71
JO - Trends in Endocrinology and Metabolism
JF - Trends in Endocrinology and Metabolism
IS - 1
ER -
